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Publications

2005

RESEARCH PAPERS AND REFEREED ARTICLES

1. Adrogue JV, Sharma S, Ngumbela K, Essop MF, Taegtmeyer H. Acclimatization to chronic hypobaric hypoxia is associated with a differential transcriptional profile between the right and left ventricle. Mol Cell Biochem 2005; 278:71-78.

2. Apstein CS, Opie LH. A challenge to the metabolic approach to myocardial ischaemia. Eur Heart J 2005; 26: 956-959.

3. Badri M, Maartens G, Bekker L-G, Wood R. The spectrum and prognosis of AIDS defining illnesses in Cape Town. Southern African Journal of HIV Medicine 2005; June (19): 11-16.

4. Baker M, Gaukrodger N, Mayosi BM, Imrie H, Farrall M, Watkins H, Connell JMC, Avery PJ, Keavney B. Association Between Common Polymorphisms of the Proopiomelanocortin Gene and Body Fat Distribution: A Family Study. Diabetes 2005; 54: 2492-2496.

5. Barnes KI, Durrheim DN, Little F, Jackson A, Mehta U, Allen E, Dlamini SS, Tsoka J, Bredenkamp B, Mthembu DJ, White NJ, Sharp BL. Effect of Artemether-Lumefantrine Policy and Improved Vector Control on Malaria Burden in KwaZulu-Natal, South Africa. PLOS Medicine 2005; 2(11): e330.

6. Barnes KI, Abdulla S. Treating malaria with artemisinin-based combinations: challenges for policy makers. Science and Development Network 2005 Policy Briefs (www.scidev.net/malaria).

7. Barnes KI, White NJ. Population biology and antimalarial resistance: The transmission of antimalarial drug resistance in Plasmodium falciparum. Acta Trop. 2005; 94(3): 230-240.

8. Batchelder K, Mayosi BM. Pentoxifylline for heart failure: a systematic review. South African Medical Journal 2005; 95: 171-175.

9. Benatar S R, Daar A S, Singer P A. Global Health Challenges: The Need for an Expanded Discourse on Bioethics. Public Library of Science Medicine PLOS; 2005; 2(7): 100-102.

10. Benatar S R, Fleischer T. Ethical and Policy Implications of Clinical Drug Trials Conducted in Developing Countries. Harvard Health Policy Review 2005; 6(1): 97-105.

11. Benatar S R, Fox R C. Meeting Threats to Global Health: A Call for American Leadership. Perspectives in Biology & Medicine 2005; 48(3): 344-361.

12. Benatar S R. Achieving Gold Standards in Ethics and Human Rights in Medical Practice. Public Library of Science Medicine PLOS2005; 2(8): 1-2.

13. Benatar S R. Moral imagination: the missing component in global health. Public Library of Science Medicine PLOS 2005; 2(12): 1207-1210.

14. Benatar S R. Why Tuberculosis Persists as a Global Problem. Tuberculosis 2005; 9(3): 235. 3

15. Benatar S R. Towards progress in resolving dilemmas in international research ethics. Journal of Law, Medicine and Ethics. 2004; 32: (4) 574-582 (too late for 2004 report)

16. Bicanic T, Wood R, Bekker L-G, Darder M, Meintjes G, Harrison TS. Antiretroviral rollout, antifungal roll-back: access to treatment for cryptococcal meningitis. The Lancet Infectious Diseases 2005; 5: 530-531.

17. Blackhurst DM, Marais AD. Alcohol - foe or friend? S Afr Med J 2005; 95: 648-654.

18. Blom DJ, Firth JC. A clinical approach to dyslipidaemia. SA Heart J 2005; 2(3): 20-31.

19. Blom DJ, Marais AD. Severe hypertriglyceridemia in a patient with lupus. Am J Med 2005; 118: 443-447.

20. Blom DJ, O’Neill FH, Marais AD. Screening for dysbetalipoproteinemia by plasma cholesterol and apolipoprotein B concentrations. Clinical Chemistry 2005; 51: 904-907.

21. Broomberg CJ, McCurdie FJ, Kahn D. Prospective audit of deaths at a teaching hospital. Transplantation Proceedings 2005; 37: 556-557.

22. Burch VC, Zabow T, Gibbs T, Aubin L, Jacobs B, Hift RJ. A structured assessment of the procedural skills of South African medical graduates at commencement of their preregistration year. Medical Education 2005; 39: 723-731.

23. Charlton KE, Steyn K, Levitt NS, Zulu JV, Jonathan D, Veldman FJ, Nel JH. Ethnic differences in intake and excretion of sodium, potassium, calcium and magnesium in South Africans. Eur J Cardiovasc Prev Rehabil. 2005 Aug; 12(4): 355-362.

24. Charlton KE, Steyn K, Levitt NS, Zulu JV, Jonathan D, Veldman FJ, Nel JH. Diet and blood pressure in South Africa: Intake of foods containing sodium, potassium, calcium, and magnesium in three ethnic groups. Nutrition. 2005 Jan; 21(1): 39-50.

25. Chiyanzu, I., Clarkson, C., Smith, P.J., Lehman, J., Gut, J., Rosenthal, P.J. and Chibale, K. Design, Synthesis and Antiplasmodial Evaluation in vitro of New 4-Aminoquinoline Isatin derivatives. Bioorganic & Medicinal Chemistry 2005; 13: 3249-3261.

26. Chukwujekwu JC, Smith P, Coombes PH, Mulholland DA, van Staden J. Antiplasmodial diterpenoid from the leaves of Hyptis suaveolens J Ethnopharmacology 2005; 102: 295-297.

27. Chung-Pu Wu , van Schalkwyk DA, Taylor D, Smith PJ, Chibale K. Reversal of Chloroquine Resistance in Plasmodium falciparum by 9-Xanthene Derivatives. IJAA 2005; 26: 170-175.

28. Clausen T, Romoren TI, Ferreira M, Kristensen P, Ingstad B, Holmboe-Ottesen G. chronic diseases and health inequalities in older persons in Botswana (Southern Africa): A national survey. The Journal of Nutrition, Health & Aging 2005; 9(6):455-461.

29. Combrinck M, Williams J, de Berardinis MA, Warden D, Puopolo M, Smith AD, Minghetti L. Levels of CSF prostaglandin E2, cognitive decline, and survival in alzheimer’s disease. J Neurol Neurosurg Psychiatry 2005; 77: 85-88.

30. Commerford PJ. Valvular heart disease in South Africa in 2005. SAMJ 95:8: 568-574. 4

31. Connor M, Rheeder P, Bryer A, Meredith M, Beukes M, Dubb A, Fritz V, on behalf of the South African Stroke Foundation. The South African stroke risk in general practice study. S Afr Med J 2005; 95(5); 334-338.

32. Dakshinamurthy A G, Novitzky N, Bharadwaj R and Prakhya B M. Cytogenetic analysis of 52 Indian patients with de novo myelodysplastic syndromes – a comparative analysis of results with reports from Asia. Annuals in Hematology 2005; 84: 298-303.

33. Den Boon S, Bateman ED, Enarson DA, Borgdorff MW, Verver S, Lombard CJ, Irusen E, Beyers N, White NW. Development and evaluation of a new chest radiograph reading and recording system for epidemiological surveys of tuberculosis and lung disease. Int J Tuberc Lung Dis 2005; 9(10): 1088-1096.

34. Den Boon S, van Lill SWP, Borgdorff MW, Verver S, Bateman ED, Lombard CJ, Enarson DA, Beyers N. Association between smoking and tuberculosis infection: a population survey in a high tuberculosis incidence area. Thorax 2005; 60: 555-557.

35. du Toit EF, Rossouw E, Salie R, Opie LH, Lochner A. Effect of sildenafil on reperfusion function, infarct size, and cyclic nucleotide levels in the isolated rat heart model. Cardiovasc Drugs Ther 2005; 19: 23-31.

36. Dzinjalamala FK, Macheso A, Kublin JG, Taylor TE, Barnes KI, Molyneux ME, Plowe CV, Smith PJ. (2005) The association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxine-pyrimethamine in Malawian children. Antimicrob Agents Chemotherapy 2005; 49(9): 3601-3606.

37. Dzinjalamala FK, Macheso A, Kublin JG, Taylor TE, Barnes KI, Molyneux ME, Plowe CV, Smith PJ. Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated Plasmodium falciparum malaria. Am J Trop Med Hygiene 2005; 72(3): 267-272.

38. Eastman R, Epilepsy in South Africa. Acta Neurol Scand 2005; 181(suppl): 8-11.

39. Eichenfield LF, Lucky AW, Langley RGB, Lynde C, Kaufmann R, Todd G, Linsley L, Barbier N and Felser JM. Use of pimecrolimus cream 1% (Elidel) in the treatment of atopic dermatitis in infants and children: the effects of ethnic origin and baseline disease severity on treatment out. Int J Dermatol 2005, 44: 70-75.

40. Elandalloussi, L.M., Adams, B. and Smith P.J. ATPase activity of purified plasma membranes and digestive vacuoles from Plasmodium falciparum Molecular and Biochemical Parasitology 2005; 141: 49-56.

41. Ericsson K, Bantje TA, Huber RM, Borg S, Bateman ED. Cost-effectiveness analysis of budesonide/formoterol compared with fluticasone in moderate-persistent asthma. Respiratory Medicine 2005. Epub ahead of print: DOI: 10.1016/j.rmed.2005.09.032.

42. Fairall LR, Zwarenstein M, Bateman ED, Bachmann M, Lombard C, Majara BP, Joubert G, English RG, Bheekie A, van Rensburg D, Mayers P, Peters AC, Chapman RD. Effect of educational outreach to nurses on tuberculosis case detection and primary care of respiratory illness: pragmatic cluster randomised controlled trial. Br Med J 2005; 331: 750-754.

43. Ferreira M. Elder abuse in Africa: what policy and legal provisions are there to address the violence Journal of Elder Abuse & Neglect 2004; 16(2): 17-32. (too late for 2004 report) 5

44. Ferreira M. Research on ageing in Africa: what do we have, not have and should we have? Generations Review 2005; 15(2): 32-35.

45. Gaziano TA, Steyn K, Cohen DJ, Weinstein MC, Opie LH. Cost-effectiveness analysis of hypertension guidelines in South Africa: absolute risk versus blood pressure level. Circulation 2005; 112: 3569-3576.

46. Gottlieb AB, Griffiths CEM, Ho VC, Lahfa M, Mrowietz U, Murrell DF, Ortonne J-P, Todd G, Cherill R, Marks I, Emady-Azar S and Paul CF for the Multi-Centre Investigator Group. Oral pimecrolimus in the treatment of moderate to severe chronic plaque-type psoriasis: a double-blind, multicentre, randomised, dose-finding trial. Br J Dermatol 2005, 152: 1219-1227.

47. Gottschalk G, Todd G. Allergies in the workplace - Lettuce allergy. Curr Allergy Clin Immunol 2005, 18(3): 13-15.

48. H McIlleron, J Norman, P Wash, P Smith. Quantification of rifampicin in urine identifies patients with low plasma concentrations. Int J Tuberc Lung Dis 2005; 11(9): suppl 1. 36th World Conference on Lung Health of IUATLD. PC-2065-22.

49. Haque M, Navsa M, Hayden S, Dennison CR, Levitt NS. Barriers to initiating insulin therapy in patients with type 2 diabetes mellitus in public-sector primary health care centres in Cape Town. S Afr Med J 2005; 95: 798-802.

50. Hatherill M, Salie S, Waggie Z, Lawrenson J, Hewitson J, Reynolds L, Argent A. Hyperchloraemic metabolic acidosis following open cardiac surgery. Arch Dis Child 2005; 90: 1288-1292.

51. Heckmann JM, Lambson EMT, Little F, Owen EP. Thiopurine methyltransferase (TPMT) heterozygosity and enzyme activity as predictive tests for the development of azathioprinerelated adverse events. J Neurological Sciences 2005; 231: 71-80.

52. Hift RJ, Meissner PN. An analysis of 112 acute porphyric attacks in Cape Town, South Africa. Medicine 2005; 84(1): 48-60.

53. Jerald J. Nair, William E. Campbell, Reto Brun, Francesc Viladomat, Carles Codina and Jaume Bastida. Alkaloids from Nerine filifolia. Phytochemistry 2005; 66(3): 373-382.

54. Juniper EF, Bousquet J, Abetz L, Bateman ED, for the GOAL Committee. Identifying “well-controlled” and “not well-controlled” asthma using the Asthma Control

Questionnaire. Respiratory Medicine 2005. Epub ahead of print: DOI: 10.1016/j.rmed.2005.08.012.

55. Kahn D, Spearman CWN, Mall A, Shephard EG, Engelbrecht G, Lotz Z, Tyler M. Effect of rapamycin on the healing of the bile duct. Transplantation Proceedings 2005; 37: 832-833.

56. Kahn D, Spearman CWN, Mall A, Shephard EG, Engelbrecht G, Lotz Z, Tyler M. The effect of rapamycin on the healing of the ureteric anastomosis and wound healing. Transplantation Proceedings 2005; 37: 830-831.

57. Kampmann B, Hemingway C, Stephens A, Davidson R, Goodsall A, Anderson S, Nicol M, Scholvinck E, Relman D, Waddell S, Langford P, Sheehan B, Semple L, Wilkinson KA, Wilkinson RJ, Ress S, Hibberd M, Levin M. Acquired predisposition to mycobacterial 6 disease due to autoantibodies to IFN-g. Journal of Clinical Investigation 2005; 115(9): 2480-2488.

58. Keavney B, Mayosi B, Gaukrodger N, Imrie H, Baker M, Fraser R, Ingram M, Watkins H, Farrall M, Davies E, Connell J. Genetic Variation at the Locus Encompassing 11-{beta}Hydroxylase and Aldosterone Synthase Accounts for Heritability in Cortisol Precursor (11-Deoxycortisol) Urinary Metabolite Excretion. Journal of Clinical Endocrinology and Metabolism. 2005; 90: 1072-1077.

59. Kgokong, K.L. Smith, P.J. and Matsabisa, G.M. (2005) 1,2,4-Triazino-[5,6b]indole derivatives:effects of the trifluoromethyl group on in vitro antimalarial activity Bioorganic and Medicinal Chemistry 2005; 13: 2935-2942.

60. Khumalo NP, Dawber RPR and Ferguson DJP. Apparent fragility of African hair is unrelated to the cystine-rich protein distribution: a cytochemical electron microscopic study. Exp Dermatol 2005, 14(4): 311-314.

61. Khumalo NP, Kirtschig G, Middleton P, Hollis S, Wojnarowska F and Murell D. Interventions for bullous pemphigoid . Cochrane Database Syst Rev 2005 20(3):CD 002292.

62. Khumalo NP. African Hair morphology: macrostructure to ultrastructure. Int J Dermatol 2005, 44(suppl. 1):10-12.

63. Kjaer A, Meyer C, Wachtell K, Olsen MH, Ibsen H, Opie L, Holm S, Hesse B. Positron emission tomographic evaluation of regulation of myocardial perfusion in physiological (elite athletes) and pathological (systemic hypertension) left ventricular hypertrophy. Am J Cardiol 2005; 96: 1692-1698.

64. Koegelenberg CFN, Theron J, Brundyn K, Bolliger CT, Marais AD, Diacon AH. A patient with a persistent pleural effusion. Respiration 17 August 2005; published online: DOI: 10.1159/000087687.

65. Kongnyuy EJ, Wiysonge SUC. Interventions to reduce haemorrhage during myomectomy for fibroids. (Protocol) The Cochrane Database of Systematic Reviews 2005, Issue 3. Art. No.: CD005355. DOI: 10.1002/14651858.CD005355.

66. Langdon G, Wilkins J, McFadyen L, McIlleron H, Smith PJ, Simonsson USH. Population pharmacokinetics of rifapentine and its primary desacetyl metabolite in South African tuberculosis patients Antimicrobial Agents and Chemotherapy 2005; 49(11): 4429 - 4436.

67. Lawn SD, Badri M, Wood R. Tuberculosis among HIV-infected patients receiving HAART: long term incidence and risk factors in a South Africa cohort. AIDS 2005; 19: 2109-2116.

68. Lawn SD, Bekker LG, Miller RF. Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals. Lancet Infect Dis 2005; 5: 361-373.

69. Lawn SD, Bekker LG, Myer L, Orrell C, Wood R. Cryptococcocal immune reconstitution disease: a major cause of early mortality in a South African antiretroviral programme. AIDS 2005; 19(17): 2050-2052.7

70. Lawn SD, Bekker LG, Wood R. How effectively does HAART restore immune responses to Mycobacterium tuberculosis? Implications for tuberculosis control. AIDS 2005; 19: 1113-1124.

71. Lawn SD, Myer L, Orrell C, Bekker LG, Wood R. Early mortality among patients accessing a community-based antiretroviral programme in South Africa: implications for programme design. AIDS 2005; 19: 2141-2148.

72. Lawn SD, Wood R. Incidence of tuberculosis during highly active antiretroviral treatment in high-income and low-income countries. Clin Infect Dis 2005; 41: 1783-1786.

73. Lecour S, Owira P, Opie LH. Ceramide-induced preconditioning involves reactive oxygen species. Life Sciences 2005. Epub ahead of print.

74. Lecour S, Rochette L, Opie L. Free radicals trigger TNF alpha-induced cardioprotection. Cardiovascular Research 2005; 65: 239-243.

75. Lecour S, Suleman N, Deuchar GA, Somers S, Lacerda L, Huisamen B, Opie LH. Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase). Circulation 2005; 112: 3911-1938.

76. Legg C, Young L, Bryer A. Training sixth-year medical students in obtaining case-history information from adults with aphasia. Aphasiology 2005; 19(6): 559-575.

77. Levitt NS, Lambert EV, Woods D, Seckl JR, Hales CN. Adult BMI and fat distribution but not height amplify the effect of low birthweight on insulin resistance and increased blood pressure in 20-year-old South Africans. Diabetologia. 2005 Jun; 48(6): 1118-1125.

78. Levitt NS, Lambert EV, Woods DL, Hales CN, Andrews R, Seckl JR. Impaired glucose tolerance and elevated blood pressure in low birth weight, non-obese young South Africans: early programming of cortisol axis. J Clin Endocrinology & Metabolism 2005; 85: 4611-4618.

79. Mabuza A, Govere J, la Grange K, Mngomezulu N, Allen E, Zitha A, Mbokazi F, Durrheim D, Barnes K. (2005) Therapeutic efficacy of sulfadoxine-pyrimethamine for

Plasmodium falciparum malaria. S Afr Med J 2005; 95(5): 346-349.

80. Makaula S, Lochner A, Genade S, Sack MN, Awan MM, Opie LH. H-89, a non-specific inhibitor of protein kinase A, promotes post-ischemic cardiac contractile recovery and reduces infarct size. J Cardiovasc Pharmacol 2005; 45: 341-347.

81. Malenga G, Palmer A, Staedke S, Kazadi W, Mutabingwa T, Ansah E, Barnes KI, Whitty CJ. Antimalarial treatment with artemisinin combination therapy in Africa. Br Med J 2005; 331(7519): 706-707.

82. Mamabolo RL, Alberts M, Steyn NP, Delemarre-van de Waal HA, Levitt NS. Prevalence and determinants of stunting and overweight in 3-year-old black South African children residing in the Central Region of Limpopo Province, South Africa. Public Health Nutrition 2005 Aug; 8(5): 501-508.

83. Marais A.D. Lipids, Lipoprotein metabolism and their derangements. SA Heart J 2005; 2(3): 8-18. 8

84. Marais AD, Firth JC. The diagnosis and management of familial hypercholesterolaemia. Eur Rev Med Pharmacol Sci 2005; 9: 141-149.

85. Marais BJ, Obihara CC, Gie RP, Schaaf HS, Hesseling AC, Lombard C, Enarson D, Bateman ED, Beyers N. The prevalence of symptoms associated with pulmonary tuberculosis in randomly selected children from a high burden community. Arch Dis Child 2005; 90: 1166-1170.

86. Mayosi BM, Avery PJ, Baker M, Gaukrodger N, Imrie H, Green FR, Farrall M, Watkins H, Keavney B. Genotype at the -174 G/C polymorphism of the interleukin-6 gene is associated with carotid intimal-medial thickness: family study and meta-analysis. Stroke 2005; 36: 2215-2219.

87. Mayosi BM, Burgess LJ, Doubell AF. Tuberculous Pericarditis. Circulation 2005; 112: 3608-3616.

88. Mayosi BM, Gaukrodger N, Imrie H, Avery P, Baker M, Connell JMC, Watkins H, Farrall M, Keavney B. A rare variant of the leptin gene has large effects on blood pressure and carotid intima-medial thickness: study of 1428 individuals in 248 families. Journal of Medical Genetics 2005; 42: 474-478.

89. Mayosi BM. SAMJ – Africa’s top open access medical journal. South African Medical Journal 2005; 95: 809.

90. McCarthy J, McLeod CJ, Minners J, Essop MF, Ping P, Sack MN. PKCepsilon activation augments cardiac mitochondrial respiratory post-anoxic reserve--a putative mechanism in PKCepsilon cardioprotection. J Mol Cell Cardiol 2005; 38: 697-700.

91. McCulloch MI, Burger H, Spearman CWN, Cooke L, Goddard E, Gajjar P, Numanoglu A, Rode H, Kahn D, Millar AJW. Nephrotoxic effects of immunosuppressant therapy in pediatric liver transplant recipients. Transplantation Proceedings 2005; 37: 1220-1223.

92. McCurdie FJ, Pascoe MD, Broomberg CJ, Kahn D. Outcome of assessment of potential donors for live donor kidney transplants. Transplantation Proceedings 2005; 37: 605-606.

93. Mciza Z, Goedecke JH, Steyn NP, Charlton K, Puoane T, Meltzer S, Levitt NS, Lambert EV. Development and validation of instruments measuring body image and body weight dissatisfaction in South African mothers and their daughters. Public Health Nutrition 2005 Aug; 8(5): 509-519.

94. Mehta SR, Eikelboom JW, Demers C, Maggioni AP, Commerford PJ, Yusuf S. Congestive heart failure complicating non-ST segment elevation acute coronary syndrome: incidence, predictors, and clinical outcomes. Can J Physiol Pharmacol 83: 98-103.

95. Michelangelo OASIS 5 Steering Committee. Design and rationale of the MICHELANGELO Organization to Assess Strategies in Acute Ischemic Syndromes (OASIS)-5 trial program evaluating fondaparinux, a synthetic factor Xa inhibitor, in patients with non-ST-segment elevation acute coronary syndromes. Am Heart J 2005; 150: 1107-1114.

96. Mwipatayi BP, Jeffery PC, Beningfield SJ, Matley PJ, Naidoo NG, Kalla AA, Kahn D. Takayasu arteritis: clinical features and management: report of 272 cases. ANZ J Surgery 2005; 75(3): 110-117.  9

97. Naoumova RP, Tosi I, Patel D, Neuwirth C, Horswell S, Marais AD, van Heyningen C, Soutar AK. Severe hypercholesterolaemia in four British families with the D374Y mutation in the PCSK9 gene: long term follow-up and treatment response. Arterioscler Thromb Vasc Biol 2005; 25: 2654-2660.

98. Ngwanya RM. Primary cicatricial alopecia. Int J Dermatol 2005, 44(suppl. 1):18-21. 99. Novitzky N, Thomas V, Hale G and Waldmann H. Myeloablative conditioning is well tolerated by older patients receiving T-cell depleted grafts. Bone Marrow Transplantation 2005; 36: 675-682.

100. Novitzky N, Thomson J, Abrahams L, Du Toit C and Mcdonald A. Thrombotic thrombocytopenic purpura in patients with retroviral infection is highly responsive to plasma infusion therapy. British Journal of Haematology 2005; 128: 373-379.

101. Ntsekhe M, Hakim J. Impact of Human Immunodeficiency Virus Infection on Cardiovascular Disease in Africa. Circulation 2005; 112: 3602-3607.

102. O’Byrine PM, Bisgaard H, Godard PP, Pistolesi M, Palmqvist M, Zhu Y, Ekstrom T, Bateman ED. Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care med 2005; 171: 129-136.

103. Obihara CC, Marais BJ, Gie RP, Potter P, Bateman ED, Lombard CJ, Beyers N, Kimpen JL. The association of prolonged breastfeeding and allergic disease in poor urban children. Eur Respir J 2005; 25(6): 970-977.

104. Okreglicki A. Sudden Cardiac Death in children and young adults. SA Heart J 2005; 2(2): 46-58.

105. Opie LH, Mayosi BM. Cardiovascular Disease in Sub-Saharan Africa. Circulation 2005; 112: 3536-3540.

106. Opie LH, Seedat YK. Hypertension in sub-Saharan African populations. Circulation 2005; 112: 3562-3568.

107. Pearce R, Malisa A, Kachur SP, Barnes K, Sharp B, Roper c. (2005) Reduced variation around drug resistant dhfr alleles in African Plasmodium falciparum. Mol Biol Evol 2005; 22(9): 1834-1844.

108. Rabe KF, Bateman ED, O’Donnell D, Witte S, Bredenbroker D, Bethke TD. Roflumilast – an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. The Lancet 2005; 366: 563-571.

109. Rayner BL, Goodman H, Opie LH. The chest radiograph: a useful investigation in the evaluation of hypertensive patients. Am J Hypertens 2004; 17: 507-510. (too late for 2004 report).

110. Robertson KA, Volmink JA, Mayosi BM. Antibiotics for the primary prevention of acute rheumatic fever: a meta-analysis. BMC Cardiovascular Disorders 2005; 5: 11.

111. Robertson KA, Volmink JA, Mayosi BM. Lack of adherence to the national guidelines on the prevention of rheumatic fever. South African Medical Journal 2005; 95: 52-56. 10

112. Ross IL, Marshall D, Okreglicki A, Isaacs S, Levitt NS. Amiodarone-induced thyroid dysfunction. S Afr Med J 2005; 95(3): 180-183.

113. Sanne I, Mommeja-Marin H, Hinkle J, Bartlett JA, Lederman MM, Maartens G, Wakeford C, Shaw A, Quinn J, Gish RG, Rousseau F. Severe Hepatotoxicity Associated with Nevirapine Use in HIV-Infected Patients. Journal of Infectious Diseases 2005; 191: 825-829.

114. Shapiro K, Benatar S R. HIV Prevention Research and Global Inequality: Steps Towards Improved Standards of Care. Journal of Medical Ethics 2005; 31: 39-47.

115. Shey MS, Kongnyuy EJ, Shang JD, Wiysonge CSU. A combination drug of abacavirlamivudine-zidovudine (Trixivir) for treating HIV infection and AIDS. The Cochrane Database of Systemic Reviews 2005, Issue 4. Art. No.: CD005481. DOI: 10.1002/14651858.CD005481. October 2005.

116. Sirgel FA, Fourie PB, Donald PR, Padayatchi N, Rustomjee R, Levin J, Roscigno G, Norman J, McIlleron H, Mitchison DA, and the Rifapentine EBA Collaborative Study Group. The early bactericidal activities of rifampin and rifapentine in pulmonary tuberculosis. Am J Respiratory and Critical Care Medicine 2005; 172(1):128-35.

117. Sliwa K, Damasceno A, Mayosi BM. Epidemiology and Etiology of Cardiomyopathy in Africa. Circulation 2005; 112: 3577-3583.

118. Smit J, Middelkoop K, Myer L, Lindegger G, Swartz L, Seedat S, Tucker T, Wood R, Bekker LG, Stein DJ. Socio-behaviour challenges to phase III HIV vaccine trials in sub-Saharan Africa. Afr Health Sci 2005; 5(3): 198-206.

119. Spearman CWN, McCulloch M, Millar AJW, Burger H, Numanoglu A, Goddard E, Cooke L, Cywes S, Rode H, Kahn D. Liver transplantation for children: Red Cross Children’s Hospital experience. Transplantation Proceedings 2005; 37: 1134-1137.

120. Steyn K, Sliwa K, Hawken S, Commerford P, Onen C, Damasceno A, Ounpuu S, Yusuf S for the INTERHEART Investigators in Africa. Risk Factors Associated With Myocardial Infarction in Africa. The INTERHEART Africa Study. Circulation 2005; 112: 3554-3561.

121. Waako PJ, Smith PJ, Folb PI. In Vitro interactions of Aspilia africana (Pers.) C.D. Adams, a traditional antimalarial medicinal plant, with artemisinin against Plasmodium falciparum J. Ethnopharmacology 2005; 102: 262-268.

122. Waako, P.J., Gumede, B., Smith, P.J. and Folb, P. The in vitro antiplasmodial activity of extracts from Cardispermum halicacabum L. and Momordica foetida Schumch. Et Thonn and the effect of their water extracts on disease progress in a muring model of cerebral malaria. J. Ethnopharmacology 2005; 99: 137-143.

123. Wilkinson A, Davidson J, Dotta F, Home PD, Keown P, Kiberd B, Jardine A, Levitt N, Marchetti P, Markell M, Naicker S, O’Connell P, Schnitzler M, Standl E, Torregosa J-V, Uchida K, Valantine H, Villamil F, Vincenti F, Wissing M. Guidelines for the treatment and management of new-onset diabetes after transplantation. Clinical transplantation 2005; 19(3): 291-298. 11

124. Wilson D, Nachega J, Chaisson R, Maartens G. Diagnostic yield of peripheral lymph node needle-core biopsies in HIV infected adults with suspected smear negative tuberculosis. International Journal of Tuberculosis and Lung Disease 2005; 9: 220-222.

125. Wiysonge CS, Mawo JN, Ticha JM, Nomo E, Shey MS. Migration and measles. Int J Epidemiol 2005; 34: 1443-1444.

126. Wiysonge CS, Njamnshi AK, Nomo E, Shey MS. Eradication of poliomyelitis. Lancet 2005; 355: 1163-1164.

127. Wiysonge CS, Shey MS, Shang JD, Sterne JAC, Brocklehurst P. Vaginal disinfection for preventing mother-to-child transmission of HIV infection. The Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003651.pub2. DOI:10.1002/14651858.CD003651.pub2. October 2005.

128. Wiysonge CS, Shey MS, Sterne JAC, Brocklehurst P. Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection. The Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003648.pub2. DOI:10.1002/14651858.CD003648.pub2. October 2005.

129. Wolmarans KH, Marais AD. Carotid intima-media thickness and dyslipidaemia. SA Heart J 2005; (3): 81-87.

130. Wood R. Nevirapine toxicity – implications for management of South African patients. S Afr Med J 2005; 95(4): 253-256.

131. Yusuf S, Hawken S, Ôunpuu S, Bautista L, Franzosi MG, Commerford P, Lang KC, Rumbolt Z, Onen CI, Lisheng L, Tanomsup S, Wangai P Jr, Razak F, Sharma AM, Anand SS on behalf of the INTERHEART Study Investigators. Obesity and the risk of myocardial infarction in 27 000 participants from 52 countries: a case control study. Lancet 2005; 366: 1640-1649.

Articles in press

1. Chukwujekwu JC , van Staden J, Smith PJ. Antibacterial, anti-inflammatory and antimalarial activities of some Nigerian medicinal plants. South African Journal of Botany (in press)

2. Fraction K. Dzinjalamala, Allan Macheso, James G. Kublin, Terrie E Taylor, Karen I. Barnes, Malcolm E. Molyneux, Christopher V. Plowe, Peter J. Smith. The association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxinepyrimethamine in Malawian children Antimicrobial Agents and Chemotherapy

3. Jaspan HB, Lawn SD, Safrit JT, Bekker LG. The maturing immune system: implications for development and testing HIV-1 vaccines for children and adolescents. AIDS 2005.

4. Rayner BL, Trinder Y, Baines D, Isaacs S, Opie LH. The effect of losartan versus candesartan on uric acid, renal function and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics. Am J Hypertension 2005. 12

NON-PEER REVIEWED ARTICLES

1. Chisholm B, Kredo T. Antiretroviral therapy: the basics. CME 2005; 23(5): 246-250.

2.Hift RJ. Fatty liver disease: steatosis and steatohepatitis. CME 2005; 23: 384-388.

3. Maartens G. Debate: Initiating antiretroviral therapy. Southern African Journal of HIV medicine 2005; Sept (20): 49-50.

4. Maartens G. The immune-compromised traveller. CME 2005; 23: 126-129.

5. Mayosi BM. Genetics and molecular diagnosis of cardiomyopathy: what every doctor should know. CME 2005; 23: 22-25.

6. Meissner PN, Hift RJ. Diagnosis of porphyria in South Africa. CME 2005; 23: 412-414.

7. Michell WL. Who is too sick for the ICU? S Afr J Crit Care 2005; 21: 8.

8.Onia R. More about: antiretrovirals. CME 2005; 23(5): 260-261.

9. Swart A, Harris V. Drug interactions with tuberculosis therapy. CME 2005; 23(2): 56-60.

10. Wilson D, Maartens G. Diagnosing tuberculosis in adults: opportunities and challenges. CME 2005; 23(2): 85-91.

BOOKS

1. L H Opie, D M Yellon (Editors). Cardiology at the Limits. Stanford Writers, Cape Town, 2005.

2. L H Opie, D M Yellon (Editors). Diabetes at the Limits. Stanford Writers, Cape Town, 2--5.

CHAPTERS IN BOOKS

1. Barnes KI, Blumberg L, Molyneux ME. Malaria Chapter. In Oxford Handbook of Paediatrics for Developing Countries 6th Edition. Harrison VH (Ed). Oxford University Press: Cape Town 2004 (ISBN 0 19 578690 4) pp 321-329.

2. Benatar SR. Health law and sustainable development. Implications for health and health care: expanding the discourse on ethics and health. In: Sustainable Justice: Reconciling Economic, Social and Environmental Law. M C Cordonier Segger, C G Weeramantry (Eds) Martinus Nijhoff Publishers: Leiden 2005, pp 381-387.

3. Benatar SR. Bioethics and Society: a view from South Africa. In: Bioethica ou Bioeticas: na evolutucao das sociedades (Bioethics and its impact on the evolution of societies). M do Ceu Patrao Neves, Manuela lima (Eds). Edicao Luso-Brasileira: Portugal 2005, pp 377-380.13

4. Benatar SR. Global disparities in health and human rights: a critical commentary. In: Ethical Health Care. P Illingworth, WE Parmet (Ed). Pearson Education Inc (Prentice Hall): Upper Saddle River, New Jersey 2005, pp 425-433.

5. Benatar SR. Retos eticos en el desarraollo de nuevas interventiones (Ethical challenges in the development of new interventions. In: Salud y Desarrollo: Retod para el siglo XX1. Mocumbi PM, Carmi J, Jansa J M (Eds). Fundacio IMIM: Barcelona, 2005 pp 197-207.

6. Benatar SR. The HIV/AIDS pandemic: a sign of instability in a complex global system. In: Ethics and AIDS in Africa: the challenge to our thinking. Van Niekerk AA, Kopelman L (Eds). Cape Town: David Philip Press 2005, pp71-83.

7. Brice EAW, Commerford PJ. Rheumatic Fever and Valvular Heart Disease. In: Essential Cardiology: Principles and Practice. 2nd Edition. Ed: Clive Rosendorff. Human Press Inc, New Jersey, USA. September 2005

8. Maartens G. Preventing opportunistic infections, in: Karim SS, Karim QA eds. HIV/AIDS in South Africa. Cambridge University Press, 2005, pp 454-462.

9. Nixon S, Upshur R, Robertson A, Benatar S, Thompson A, Daar A. Public health ethics. In: Public Health & Law Policy in Canada. Ries N, Caulfield T, Bailey T (Eds). Lexis Nexis: Canada, 2005, pp39-58.

10. Opie LH, Frishman WH, Sica DA. Adverse cardiovascular drug interactions and complications. In: Hurst's The Heart, 11th Edition. O'Rourke RA, Fuster V, Alexander W, Roberts R, King SB, Wellens HJJ (Eds). McGraw-Hill: New York, 2005, pp 533-554.

11. Opie LH. Calcium channel blockers: Controveries, lessons and outcomes. In: Hypertension: Companion to Brenner & Rector’s The Kidney. 2nd Edition. Oparil S, Weber MA (Eds). Elsevier Saunders: Philadelphia, 2005, pp 408-415.

12. Opie LH. Mechanisms of cardiac contraction and relaxation. In: Braunwald’s Heart Disease. A textbook of cardiovascular medicine, 7th Edition. Elsevier: Philadelphia, 2005, pp 457-489.

13. Opie LH. Ventricular function. In: Essential Cardiology. Principles and Practice, 2nd Edition. Rosendorff C (Ed). Humana Press: New Jersey. 2005, pp 37-53.

EDITORIAL

1. Marais A.D. Editorial. SA Heart J 2005; 2(3): 4-6.

2. Okreglicki A. QT-prolonging drugs: Should they ever be used? South African Journal of Psychiatry 2005; 11:2: 40-41. September 2005.

3. Opie LH. ARBs and mortality in myocardial infarction. Cardiovasc J S Afr 2005; 16: 84.

4. Rayner B. ASCOT-BPLA signals changes to hypertension guidelines. Cardiovascular Journal of South Africa 2005; 16(5): 244-245.14

5. Vinten-Johansen J, Yellon DM, Opie LH. Postconditioning: a simple, clinically applicable procedure to improve revascularization in acute myocardial infarction. Circulation 2005; 112: 2085-2088.

LETTERS

1. Benatar S R. Blinkered Objections to Bioethics: A Response to JS Taylor. Journal of Medical Ethics 2005; 31(3):180–81.

2. Lawn SD, Badri M, Wood R. Risk factors for tuberculosis among HIV-infected patients receiving antiretroviral treatment. Am J Resp Crit Care Med 2005; 172:1348.

3. Lawn SD, Myer L, Wood R. Efficacy of antiretroviral therapy in resource-poor settings: are outcomes comparable to those in the developed world? Clin Infect Dis 2005; 41: 1683-1684.

4. Mehta U, Barnes KI, Kathard H, Vugt M, Durrheim D. (2005) Comment on: Audiometric changes associated with the treatment of uncomplicated falciparum malaria with coartemether. Trans R Soc Trop Med Hyg. 2005; 99(4): 313-314.

5. Monya-Tambi I, Robertson KR, Volmink JA, Mayosi BM. Acute rheumatic fever. Lancet 2005; 366: 1355.

6. Opie LH. HIV/AIDS in South Africa. Lancet 2005; 366: 291.

In Press

1. Lawn SD, Wood R. How can earlier access to antiretroviral programmes be promoted in low-income countries? Clin Infect Dis 2005. .

2.Lawn SD. Mycobacterium-associated immune reconstitution disease: macrophages running wild? Lancet Infect Dis 2006.

3. Mehta U, Barnes KI, Harsha KB, van Vugt M, Durrheim D. Audiometric changes associated with the treatment of uncomplicated falciparum malaria with artemether-lumefantrine. (Letter). Trans Roy Soc Trop Med Hygiene.

PUBLISHED ABSTRACTS/CONFERENCE PROCEEDINGS

1. Baker M, Gaukrodger N, Mayosi B, Imrie H, Farrall M, Watkins H, Connell J, Avery P, Keavney B. Association between common polymorphisms of the pro-opiomelanocortin (POMC) gene and body fat distribution: a family study Heart 2005;91 (Suppl 1):A41.

2. Davids LM, Gottschalk G and Kidson SH. Melanocyte populations in repigmenting vitiliginous skin. Pig Cell Res 2004, 17(5):589.

3. IMPI Africa Investigators. Contemporary use of adjunctive corticosteroids in the management of tuberculous pericarditis in Africa: a matter of clinical equipoise? S Afr Med J 2005; 95(10):816-817. 15

4. IMPI Africa Investigators. HIV co-infection is associated with a high risk of death and antituberculosis drug toxicity in patients with tuberculous pericarditis. S Afr Med J 2005;95(10):816.

5. IMPI Africa Investigators. Investigation of the Management of Pericarditis in Africa (IMPI Africa). S Afr Med J 2005; 95(10): 811-814.

6. Imrie H, Mayosi B, Gaukrodger N, Avery P, Baker M, Connell J, Watkins H, Farrall M, Keavney B. A rare variant of the leptin (LEP) gene has large effects on blood pressure (BP) and carotid intima-medial thickness (CIMT): study of 1428 individuals in 248 families. Heart 2005;91 (Suppl 1): A64.

Imrie H, Mayosi BM, Baker M, Fraser R, Davies E, Ingram M, Watkins H, Farrall M, Connell J, Keavney B. Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. Heart 2005;91 (Suppl 1):A65.

8. Khumalo N, Kirtschig G, Middleton P, Hollis S, Wojnarowska F, and Murrell D. Summary of Cochrane review of interventions for bullous pemphigoid. Aus J Dermatol 2004, 45(3):A16-A17.

9. Khumalo NP and Mayosi BM. Autosomal dominant poikiloderma, tendon contracture and pulmonary fibrosis: a new variant of hereditary sclerosing poikiloderma of Weary? Br J Dermatol 2005, 153(suppl 1):72.

10. Mayosi B, Avery P, Baker M, Gaukrodger N, Imrie H, Farrall M, Watkins H, Keavney B. Association between the -174G/C polymorphism of the interleukin-6 gene and carotid atherosclerosis: family study and meta-analysis. Heart 2005;91 (Suppl 1):A15.

11. Mayosi BM. Genetic determination of ECG left ventricular hypertrophy. Cardiovascular Journal of South Africa 2005;16 (2 Suppl 1):14-15.

12. Okreglicki A, Latib A. Cardiac resynchronization therapy (CRT) – a bridge to valve replacement surgery in ‘inoperable’ LV dysfunction. Heart Rhythm 2005; 2(1S):S254.

13. Okreglicki A, Leon R, Dhanjee J. Implantable cardioverter defibrillators in arrhythmogenic right ventricular dysplasia. Chronic right ventricular sensing and pacing characteristics. SA Heart 2005; 2(3): 114.

14. Okreglicki A, Scott Millar R. Atypical atrial flutter in orthotopic heart transplantation. Evidence of donor-to-recipient atrial connection. SA Heart 2005; 2(3): 114.

15. Okreglicki A. Implantable cardioverter defibrillators (ICDs) at Groote Schuur Hospital. Review of the use, outcome and cost-effectiveness of ICDs implanted at a state hospital /academic arrhythmia clinic. SA Heart 2005; 2(3): 113.

16. Robertson KA, Volmink JA, Mayosi BM. Evidence from a Meta-Analysis of Randomized Controlled Trials Shows that Primary Prevention of Acute Rheumatic Fever with Antibiotics is Cost Effective in Developing Countries. Journal of the American College of Cardiology 2005; 45: 355A.

17. Van Zyl-Smit R, Burch V, Willcox P. The role of a medical high care unit in critical care service provision at an urban secondary level hospital in Cape Town. S A J Crit Care 2005; 21:63.16

18. Wiysonge CS, Ntsekhe M, Mayosi BM, for The IMPI Registry Study Group. Initial report of the Initiative to Iinvestigate the Optimal Management of Tubeculous Pericarditis in Africa (IMPI) Registry (abstract). Journal of the American College of Cardiology 2005; 15(3):141A-142A.

CONFERENCE PRESENTATIONS

1. Ekpebegh CO, Coetzee EJ, Levitt NS. Retrospective analysis of pregnancy outcome in type 2 diabetes: comparison of insulin and oral hypoglycaemic agent therapy at Groote Schuur Hospital from 1995 – 1997. 41st SEMDSA Congress, Johannesburg 9 – 12 April 2005.

2. Goedecke JH, Wake, DJ, Levitt NS, Lambert EV, Collins MR, Morton NM, Walker BR, Seckl JR. Insulin sensitivity and abdominal adipokine expression are not influenced by ethnicity in South African women. 41st SEMDSA Congress, Johannesburg 9 – 12 April 2005.

3. Heckmann J, Fredericks A, Evans A, Norman J, Blockman M, Lambson E, Owen E, Spearman W, Smith P. Ethical Issues in Designing Clinical Trials for Complementary and traditional Medicines Dr Marc Blockman SA Pharmacology Conference Cape Town 2005.

4. Levitt NS, Bradshaw D. The impact of HIV/AIDS on diabetes prevalence and diabetes healthcare needs in South Africa – Projections for 2010. 41st SEMDSA Congress, Johannesburg 9 – 12 April 2005.

5. McIlleron H, P Wash, A Burger, J Norman, PI Folb, P Smith. HIV-infection and rifampicin, isoniazid, pyrazinamide and ethambutol pharmacokinetcs in a cohort of South African tuberculosis patients. Proceedings of: 6th International Workshop on Clinical Pharmacology of HIV therapy. April 2005. Abstract 86.

6. Micklesfield LK, Levitt NS, Dhansay MA, Norris SA, van der Merwe L, Lambert EV. Maternal and early life influences on Calcaneal ultrasound parameters ad metacarpal morphometry in 7 – 9 year old children. 41st SEMDSA Congress, Johannesburg 9 – 12 April 2005.

7. Roberts, L., Hoppe, H., Wiehart, U., Meredith, S., Van Schalkwyk, D., Egan, J. and Weber, B. Understanding Plasmodium falciparum endocytosis: antimalarial drugs as tools. Keystone Symposium: Drugs against protozoan parasites: target selection, structural biology and medicinal chemistry. (2005) Colorado, USA.

8. Ross IL, Buchanan M, Sheppard MC, Eggo M. Activated TIE-2 expression is decreased in thyroid cancer. 41st SEMDSA Congress, Johannesburg 9 – 12 April 2005.

9. Wiehart, U, M. Rautenbach and H. Hoppe. Antimalarial properties of haemolytic antifungal compounds. Keystone Symposium: Drugs against protozoan parasites: target selection, structural biology and medicinal chemistry. (2005) Colorado, USA.

UNIVERSITY PUBLICATIONS AND PUBLICATIONS OF A POPULAR NATURE

1. Commerford PJ. Vogelpoel, Louis (Obituary). Journal of the Royal College of Physicians: Munks Roll 2005 17

2. Gottschalk G. Acne vulgaris. MIMS DTR 2005, 1:257-260.

3. Keyzer C. Severe recalcitrant acne. Modern Medicine of South Africa 2005, 30(7):52.

4. Keyzer C. Staphylococcal skin infections. Modern Medicine of South Africa 2005, 30(6):50.

5. Omar H. Topical antimicrobial agents. MIMS DTR 2005, 1:150-152.

6. Pather S. Topical anti-inflammatory agents. MIMS DTR 2005, 1:269-271.