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Publications

2007

2007

BIOETHICS

Research papers and refereed articles

Benatar SR. An examination of ethical aspects of migration and recruitment of health care professionals. Clinical Ethics 2007; (2) 2-7.

Benatar SR, Fleischer TA. Ethical issues in research in low-income countries. International Journal of Tuberculosis and Lung Diseases 2007; 11 (6) 617-23.

Benatar D. Unscientific Ethics. Hastings Center Report, Vol. 37(1), 2007, pp. 30-32.

Benatar D. Moral theories may have some role in teaching applied ethics. Journal of Medical Ethics, Vol. 33 (11), November 2007, pp 671-2.

Chapters in books

Orbinski J, Benatar SR. Drug development for visceral Leishmaniasis: a failure of the market and public policy. In: Ethical issues in international biomedical research. JV Lavery, C Grady, ER Wahl, EJ Emanuel (Eds) 0xford University Press New York 2007, pp. 90-96.

Benatar SR. New Perspectives on International Research Ethics. In: Ethics in Biomedical Research: International Perspectives. M Hayry, T Takala P Herissone-Kelly (Eds) Amsterdam & New York, Rodpoi Press 2007. p 9-19.

Benatar SR. Justice and priority setting in international health research. In: Principles of Health Care Ethics, 2nd Edition. R E Ashcroft, A Dawson, H Draper, J R McMillan (Eds) John Wiley & Sons Ltd. Chichester, England 2007, pp 733-741.

Henley LD. End of Life Care in HIV-Infected Children Who Have Died. In: Chadwick R, Kuhse H, Landman WA, Schuklenk U, Singer P (Editors). The Bioethcis Reader: Editors’ Choice. Oxford, Blackwell Publishing Ltd. 2007, pp. 576-591.

Editorial

Benatar D. The Chickens Come Home to Roost. American Journal of Public Health 2007; 97 (9): 1545-1546.

Letter

Benatar D. Grim news from the original position: A reply to Professor Doyal. Journal of Medical Ethics 2007; 33(10): 577.

Benatar S. Research Ethics Committees in Africa: Building Capacity. PLoS Medicine. 2007;4:e135.2

Works of a popular nature

Benatar SR. Budget cuts for state hospitals would undermine tradition of excellence. Cape Times 27th February 2007 p 9.

Benatar SR. Tertiary public hospital budget cuts raise critical questions. Cape Times 9th March 2007, p 8.

Book Reviews

Fleischer T. “Global Bioethics: The Collapse of Consensus”. TE Engelhardt, Jr (Ed). JAMA 297: 2287-2288 (2007).

DIVISION OF CARDIOLOGY

Research papers and refereed articles

Baker M, Rahman T, Hall D, Avery PJ, Mayosi BM, Connell JM, Farrall M, Watkins H, Keavney B. The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: A possible explanation for heterogeneity in genetic association studies of AGT and hypertension. Int J Epidemiol 2007; 36(6): 1356-1362.

Chin A, Commerford P. Non-steroidal anti-inflammatory drugs and cardiovascular risk. S Afr Med J 2007; 97(7): 500-502.

Commerford PJ. Heart disease in Africa: is there an epidemiologic transition. J Heart Disease 2007; 1(5): 12-14.

Dahya V, Mayosi BM. Assessing scimitar syndrome – use of MRI and MRA. S Afr Med J 2007; 97(4): 248-249.

Damasceno A, cotter G, Dzudie A, Sliwa K, Mayosi BM. Heart failure in sub-Saharan Africa: time for action. J Am Coll Cardiol 2007; 50(17): 1688-1693.

Engel MA, Matchaba PT, Volmink J. Corticosteroids for tuberculosis pleurisy (Review). Cochrane Database of Systematic Reviews 2007, Issue 4, Art. No. CD001876, doi:10.1002/14651858.

Mayosi BM, Somers K. Cardiomyopathy in Africa: heredity versus environment. Cardiovasc J Afr 2007; 18(3): 175-179.

Mayosi BM. Contemporary trends in the epidemiology and management of cardiomyopathy and pericarditis in sub-saharan Africa. Heart 2007; 93(10): 1176-1183.

Munro SA, Lewin SA, Smith HJ, Engel ME, Fretheim A, Volmink J. Patient adherence to tuberculosis treatment: a systematic review of qualitative research. PLOS Medicine 2007;4(7): 1230-1245.

Spottiswoode BS, Zhong X, Hess AT, Kramer CM, Meintjes EM, Mayosi BM, Epstein FH. Tracking myocardial motion from cine DENSE images using spatiotemporal phase unwrapping and temporal fitting. IEEE Transactions on Medical Imaging 2007; 26(1): 15-30.

Syed FF, Mayosi BM. A modern approach to tuberculous pericarditis. Prog Cardiovasc Dis 2007; 50(3); 218-236.

The ACTIVE Steering Committee on behalf of the ACTIVE Investigators Hamilton, Ontario, Canada. Rationale and design of ACTIVE: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events. Am J Heart 2007; 151(6): 1187-1193.

The Fifth Organization to Assess Strategies in Acute Ischemic Syndromes Investigators. Comparison of fondaparinux and enoxaparin in acute coronary syndromes. N Engl J Med 2007; 354(14): 1464-1476.

The MERLIN-TIMI 36 Randomized Trial. Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes. JAMA 2007; 297(16):1775-1783.

The OASIS-6 Randomized Trial. Effects of fondaparinux on mortality and reinfarction inpatients with acute ST-segment elevation myocardial infarction. JAMA 2007; 295 (13):1519-1530.

Wiysonge C, Bradley H, Mayosi B, Maroney R, Mbewu A, Opie L, Volmink J. Betablockers for hypertension. Cochrane Database Syst Rev 2007; January 24 (1): CD002003

Chapters in books

Mayosi BM, Somers K. Cardiomyopathy in Africa: Heredity versus Environment. In: Cardiology at the Limits VIII, edited by Lionel H Opie and Derek Yellon, 2006. pp. 67-76. ISBN: 1-919713-95-6.

Non-peer reviewed articles

Commerford P, Doubell A. Cardiology – when to refer. CME 2007; 25(11): 520-525.

Editorial

Mayosi BM. A statement of intent on the formation of the NCRP on cardiovascular and metabolic disease: a new initiative to fight heart disease, stroke, diabetes and obesity in South Africa. Cardiovasc J S Afr 18(1): 4-6.

Sanderson JE, Mayosi B, Yusuf S, Reddy S, Hu S, Chen Z, Timmis A. Global burden of cardiovascular disease. Heart 2007; 93(10): 1175.

Letters

Vaughan CL, Mayosi BM. Origins of computed tomography. Lancet 2007; 369(9568): 1168.

Wiysonge CS, Ntsekhe M, Gumedze F, Sliwa K, Ngu Blackett K, Commerford PJ, Volmink JA, Mayosi BM. Contemporary use of adjunctive corticosteroids in tuberculous piericarditis. Int J Cardiol 17 April 2007; doi: 10.1016/j.ijcard.2006.12.060.f

Works of a popular nature

Ntsekhe M, Mayosi B. Curb rheumatic heart disease. Cape Times: Times Life Supplement, 3 July 2007; p. 6.

 

DIVISION OF CLINICAL IMMUNOLOGY

Research papers and refereed articles

Davids V, Hanekom W, Gelderbloem SJ, Hawkridge A, Hussey G, Sheperd R, Workman L, Soler J, Murray RA, Ress SR, Kaplan G. Ddose-dependent immune response to Mycobacterium bovis BCG vaccination in neonates. Clinical and Vvaccine Immunology 2007; 14(2): 198-200.

Dheda K, Chang JS, Huggett JF, Kim LU, Johnson MA, Zumla A, Rook GA. The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4delta2, is not. Tuberculosis (Edinb). 2007 May;87(3):237-241.

Dheda K, Pooran A, Pai M, Miller RF, Lesley K, Booth HL, Scott GM, Akbar AN, Zumla A, Rook GA. Interpretation of Mycobacterium tuberculosis antigen-specific IFN-gamma release assays (T-SPOT.TB) and factors that may modulate test results. J Infect. 2007 Aug;55(2):169-73. Epub 2007 Apr 19.

Lala S, Dheda K, Chang JS, Huggett JF, Kim LU, Johnson MA, Rook GA, Keshavy S, Zumla A. The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis. BMC Infect Dis. 2007 Aug 16;7:96.

McIlleron H, Watkins ML, Folb PI, Ress SR, Wilkinson RJ. Rifampin levels, interferongamma release and outcome in complicated pulmonary tuberculosis. Tuberculosis (Edinb) 2007; 87: 557-64

Pai M, Dheda K, Cunningham J, Scano F, O’Brien R. T-cell assays for the diagnosis of latent tuberculosis infection: moving the research agenda forward. Lancet Infect Dis. 2007 Jun;7(6):428-38.

Pai M, Mohan A, Dheda K, Leung CC, Yew WW, Christopher DJ, Sharma SK. Lethal interaction: the colliding epidemics of tobacco and tuberculosis. Expert Rev Anti Infect Ther. 2007 Jun;5(3):385-91. Review.

DIVISION OF DERMATOLOGY

Research papers and refereed articles

Gottschalk GM, Kidson SH. Molecular analysis of vitiligo lesions reveals sporadic melanocyte survival. Int J Dermatol 2007; 46: 268-272.

Khumalo NP, Gumedze F. African hair length in a school population: a clue to disease pathogenesis? J Cosmet Dermatol 2007, 6(3): 144-151.

Khumalo NP, Jessop S, Gumedze F, Ehrlich R. Hairdressing and the prevalence of scalp disease in African adults. Br J Dermatol 2007; 157: 981-988.

Khumalo NP, Jessop S, Gumedze F, Ehrlich R. Hairdressing is associated with scalp disease in African schoolchildren. Br J Dermatol 2007; 157: 106-110.

Khumalo NP, Ngwanya RM, Jessop S, Gumedze F, Ehrlich R. Marginal traction alopecia severity score: development and test of reliability. J Cosmet Dermatol 2007; 6(4): 262-269.

Lehloenya R. The management of Stevens-Johnson syndrome and toxic epidermal necrolysis. Curr Allergy Clin Immunol 2007; 20(3): 124-128.

Maiphetlho L. Contact dermatitis in the textile industry. Curr Allergy Clin Immunol 2007; 20(1):33-35.

Oranje AP, Chosidow O, Sarvajnamurthy S, Todd G, Singh K, Scangarella N, Shawar R, Twynholm M.on behalf of the TOC100224 study team. Topical retapamulin ointment, 1%, versus sodium fusidate ointment, 2%, for impetigo: a randomised, observer-blinded, noninferiority study. Dermatology 2007; 215: 331-340.

Williams H. Contact dermatitis within the explosive industry – a case report. Curr Allergy Clin Immunol 2007; 20(3):151-154.

Books

Saxe N, Jessop S, Todd G. Handbook of Dermatology for Primary Care. A practical guide to diagnosis. 2nd Edition, Oxford University Press, Southern Africa (Pty) Ltd., 2007.

Theses and dissertations

Khumalo NP. The epidemiology of hairstyle related African hair disorders in an urban township in South Africa. PhD thesis.

Non-peer reviewed articles

Eisman S. Tinea capitis. Dermatol Review 2007; 7(1):22-28.

Jessop S. Female pattern hair loss (androgenetic alopecia). Dermatol Review 2007;7(1):14-21.

Khumalo NP. Alopecia areata. Dermatol Review 2007; 7(1):6-13.

Ngwanya RM. Classification and clinical approach to the diagnosis of alopecia. Dermatol Review 2007; 7(1):30-39.

Editorials

Khumalo NP. Eight glasses a day – the perils of pseudoscience? S Afr Med J 2007:97(8): 545

Khumalo NP. Who determines culture? S Afr Med J 2007; 97(6):385

Khumalo NP. How common is condom failure? S Afr Med J 2007;97(3):143

Letters

Khumalo NP. Yes, let’s abandon race- it does not accurately correlate with hair form. J AM Acad Dermatol 2007; 56(4):709-710.

Khumalo NP, Ngwanya RM. Traction alopecia: 2% topical minoxidil shows promise. Report of two cases. J Eur Acad Dermatol Venereol 2007; 21(3): 433-434.

Khumalo NP, Pillay K, Ngwanya RM. Acute ‘relaxer’-associated scarring alopecia: a report of five cases. Br J Dermatol 2007; 156: 1394-1396.

DIVISION OF ENDOCRINOLOGY

Research papers and refereed articles

Bradshaw D, Norman R, Lewin S, Joubert J, Schneider M, Nannan N, Groenewald P, Laubscher R, Matzopoulos R, Nojilana B, Pieterse D, Steyn K, Vos T and the SA CRA Collaborating Group. Strengthening public health in South Africa: Building a stronger evidence base for improving the health of the nation. S Afr Med J 2007:97;643-649.

Bradshaw D, Norman R, Pieterse D, Levitt NS and the South African Comparative Risk Assessment Collaborating Group. Estimating the burden of disease attributable to diabetes in South Africa in 2000. S Afr Med J. 2007 Aug;97(8 Pt 2):700-706.

Charlton KE, Macgregor E, Vorster NH, Levitt NS, Steyn K. Partial replacement of NaCl can be achieved with potassium, magnesium and calcium salts in brown bread. Int J Food Sci Nutr. 2007 Jun 6:1-14.

Charlton KE, Steyn K, Levitt NS, Jonathan D, Zulu JV, Nel JH. Development and validation of a short questionnaire to assess sodium intake. Public Health Nutr. 2008; 1(1): 83-94.

de Vries A, Holmes MC, Heijnis A, Seier JV, Heerden J, Louw J, Wolfe-Coote S, Meaney MJ, Levitt NS, Seckl JR. Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function. J Clin Invest. 2007; 117(4): 1058-67.

Dennison CR, Peer N, Lombard CJ, Kepe L, Levitt NS, Steyn K, Hill MN. Cardiovascular risk and comorbid conditions among Black South Africans with hypertension in public and private primary care settings: the HiHi study. Ethn Dis. 2007 Summer; 17(3): 477-483.

Dennison CR, Peer N, Steyn K, Levitt NS, Hill MN. Determinants of hypertension care and control among peri-urban Black South Africans: the HiHi study. Ethn Dis 2007 Summer; 17(3): 484-491.

Ekpebegh CO, Coetzee EJ, van der Merwe L, Levitt NS. A 10-year retrospective analysis of pregnancy outcome in pregestational Type 2 diabetes: comparison of insulin and oral glucose-lowering agents. Diabet Med 2007; 24: 253-258.

Evans J, Collins M, Jennings C, van der Merwe L, Söderström I, Olsson T, Levitt NS, Lambert EV, Goedecke JH. The association of interleukin-18 genotype and serum levels with metabolic risk factors for cardiovascular disease. Eur J Endocrinol 2007; 157(5): 633-640.

Mamabolo RL, Alberts M, Levitt NS, Delemarre-van de Waal HA, Steyn NP. Prevalence of gestational diabetes mellitus and the effect of weight on measures of insulin secretion and insulin resistance in third-trimester pregnant rural women residing in the Central Region of Limpopo Province, South Africa. Diabet Med 2007; 24: 233-239.

Mamabolo RL, Alberts M, Levitt NS, Delemarre-van de Waal HA, Steyn NP. Association between insulin-like growth factor-1, insulin-like growth factor-binding protein-1 and leptin levels with nutritional status in 1-3-year-old children, residing in the central region of Limpopo Province, South Africa. Br J Nutr. 2007; 98(4): 762-769.

Micklesfield LK, Levitt NS, Carstens MT, Dhansay MA, Norris SA, Lambert EV. Early life and current determinants of bone in South African children of mixed ancestral origin. Annals of Human Biology. 2007; 34: 647 - 655.

Norman R, Bradshaw D, Schneider M, Joubert J, Groenewald P, Lewin S, Steyn K, Vos T, Laubscher R, Nannan N, Nojilana B, Pieterse D and the SA CRA Collaborating Group. A comparative risk assessment for South Africa in 2000: Towards promoting health and preventing disease. S Afr Med J 2007; 97: 637-641.

Norman R, Bradshaw D, Steyn K, Gaziano T and the SA CRA Collaborating Group. Estimating the burden of disease attributable to high cholesterol in South Africa in 2000. S Afr Med J 2007; 97: 708-715.

Norman R, Gaziano T, Laubscher R, Steyn K, Bradshaw D and the SA CRA Collaborating Group. Estimating the burden of disease attributable to high blood pressure in South Africa in 2000. S Afr Med J 2007; 97: 692-698.

Pepper DJ, Levitt NS, Cleary S, Burch VC. Hyperglycaemic emergency admissions to a secondary-level hospital – an unnecessary financial burden. S Afr Med J 2007; 97(10):963-967.

Editorials

Levitt NS. Comment - A South African perspective On MODEL (Management of Diabetes for ExceLlence). SA Journal of Diabetes & Vascular Disease 2007;4 Aug/Sept:123.

Non-refereed publications / case reports

Dave JA, Levitt NS. Dysglycemia in patients with an acute stroke. Update 2007 Aug:20.

Dave JA, Varkel L, Semple P, Levitt NS. A pituitary macroadenoma presenting with hyponatremia. JEMDSA 2007.

Ekpebegh CO, van Wyk G, Crida D, Isiavwe AR, Ross IL, Levitt NS. Acute bilateral cataracts in diabetes mellitus – a report on two cases. JEMDSA June 2007; 12: 14-16.

Semple P, Fieggen G, Parkes J, Levitt N. Giant prolactinomas in adolescence: an

uncommon cause of blindness. Childs Nerv Syst 2007; 23: 213-217.

Published abstracts

Charlton K, Steyn K, Levitt N, Peer N, Jonathan D, Gogela T, Gwebushe N, Lombard C. A food-based randodmised, controlled trial to assess the impact of dietary manipulation of cations on blood pressure in black hypertensive South Africans. SA Hypertension Society Congress, Johannesburg, May 2007. Cardiovasc J Afr 2007 May-Jun;18(3 Suppl):S31.

Dave JA, May WA, Freercks R, Levitt NS. Dysglycaemia in patients presenting with an acute stroke. 42nd SEMDSA Congress, Bloemfontein, 29 June – 2 July 2007. JEMDSA 2007;12:27.

De Wet H, Levitt N, Tipping B. Executive cognitive impairment detected by simple bedside testing is associated with poor glycaemic control in people with type 2 diabetes. 42nd SEMDSA Congress, Bloemfontein, 29 June – 2 July 2007. JEMDSA 2007;12:30.

Ross, Soule S, Levitt NS, She J-X, Mienie J, Pirie F, Boulle A, Winter WE, Karlsson A, Schatz D on behalf of South African Addison Study Group. South African Addison Study. 42nd SEMDSA Congress, Bloemfontein, 29 June – 2 July 2007. JEMDSA 2007;12:44.

Peer N, Dennison C, Lombard C, Levitt N, Steyn K, Hill M. Target-organ damage in black South African patients with hypertension. SA Hypertension Society Congress, Johannesburg, May 2007. Cardiovasc J Afr 2007 May-Jun;18(3 Suppl):S24-5.

Raubenheimer PJ, Peter J, Ellard S. Diabetes and renal cysts due to a heterozygous whole gene mutation of HNF-1BETA (MODY5). 42nd SEMDSA Congress, Bloemfontein, 29 June – 2 July 2007. JEMDSA 2007;12:44.

 

DIVISION OF ACUTE GENERAL MEDICINE

(Incorporating the Departments of Medicine at GF Jooste, New Somerset, and Victoria Hospitals)

Research papers and refereed articles

Burch VC, Norman GR, Schmidt HG, van der Vleuten CPM. Are specialist certification examinations a reliable measure of physician competence? Adv Health Sci Educ Theory Pract 2007; doi: 10.1007/s10459-007-9063-5.

Longombe AO, Burch V, Luboga S, Mkony C, Olapade-Olaopa EO, Otieno-Nyunyam B, Afolabim B, Nwobodom E, Kiguli S, Burdick WP, Boulet JR, Morahan PS. Research on medical migration from Sub-Saharan medical schools: usefulness of a feasibility process to define barriers to data collection and develop a practical study. Education for Health 2007; 20(1): 27.

Pepper DJ, Levitt NS, Cleary S, Burch VC. Hyperglycaemic emergency admissions to a secondary-level hospital – an unnecessary financial burden. S Afr Med J. 2007; 97(10): 963-967.

Letter

Van Zyl Smit R, Burch V, Wilcox P. The need for appropriate critical care service provision at non-tertiary hospitals in South Africa. S Afr Med J 2007; 97(4): 268-272

DIVISION OF GASTROENTEROLOGY

Research papers and refereed articles

Epstein D, Watermeyer G, Kirsch R. Review article: the diagnosis and management of Crohn’s disease in populations with high-risk rates for tuberculosis. Alimentary Pharmacology & Therapeutics 2007, 25:1373-1388.

Levin DA, Watermeyer G, Mohamed N, Epstein DP, Hlatshwayo SJ, Metz DC. Evaluation of a locally produced rapid urease test for the diagnosis of Helicobacter pylori infection. South African Medical Journal 2007, 97(12):1281-1284.

Watermeyer GA, Shaw JM, Krige JEJ. Gastrointestinal: Acute necrotizing esophagitis (Education and Imaging). Journal of Gastroenterology & Hepatology 2007, 22:1162.

Non-peer reviewed publication/case report

Watermeyer G. Pregnancy and Inflammatory Bowel Disease. S African Gastroenterology Review 2007, 5(1):4-6.

Letter

Watermeyer G, Locketz M, Govender D, Mall A. Crohn’s disease-associated small bowel Adenocarcinoma with pre-existing low-grade dysplasia: a case report. American Journal of Gastroenterology 2007, 102(7):1545-6.

Published Abstracts

Baburajan B, Chua K, Zhen G, Levin D, Doig L, Meenan J. How safe is EUS in the Elderly? Large Series Experience to Define Procedural Risks and Complications in Patients Over the Age of 70 and 85 Years. Gastrointestinal Endoscopy 2007; 65(5): AB200.

Epstein D, Dempster G. A South African Inflammatory Bowel Disease national registry: an achievable objective. South African Medical Journal 2007, 97(8): 611.

George DJ, Epstein D, Watermeyer G, Levin D. Colectomy for Ulcerative Colitis: Inflammatory Bowel Disease Database audit at Groote Schuur Hospital, Cape Town. S Afr Medical Journal 2007, 97(8):606.

Levin DA, Epstein DP, Watermeyer G, Setshedi M, Metz DC. Outcome of patients with high-risk bleeding Peptic Ulcer Disease undergoing endoscopic intervention at Groote Schuur Hospital. South African Medical Journal 2007, 97(8): 607.

Setshedi M, Epstein D, Hift R, Winter TA, Watermeyer GA. Risk of Malignancy in patients with Inflammatory Bowel Disease treated with Azathioprine or 6-Mercaptopurine: the Cape Town experience. South African Medical Journal 2007, 97(8): 606.

Watermeyer G, Govender D, Cariem A, Tyler M, Michalowski K, Mall A. Muc-Sac is absent in Crohn’s disease-associated small bowel Adenocarcinoma and in the adjacent ulcerassociated cell lineage but in aberrantly expressed by uninvolved ileal mucosa. S Afr Medical Journal 2007, 97(8): 616.

Conference Proceedings

Epstein D. Ileocolonic tuberculosis: a diagnostic challenge. In: Tozun N, Dagli U, Mantzaris G, Scholmerich J, editors. IBD 2007 - Achievements in Research and Clinical Practice. Dordrecht: Springer 2007:45-54

THE ALBERTINA AND WALTER SISULU INSTITUTE OF AGEING IN AFRICA AND DIVISION OF GERIATRIC MEDICINE

Research papers and refereed articles

Ferreira, M. The relationship between longevity and wealth in South Africa.Les Cahiers de la FIAPA Research-Action on Ageing. Longevity: A challenge for science and society 2007, 6 (September): 101–103.

Tipping B, De Villiers L, Wainwright H, Candy S, Bryer A. Stroke in patients with human immunodeficiency virus infection. J Neurosurg Psychiatry2007 Dec; 78(12):1320–4. Epub 2007 Apr 30. PMID: 17470469.

Non-peer reviewed publications

De Villiers L, Tipping B. Falls, dizziness and syncope in the elderly – when to refer. CME 2007; 25(11): 557–562.

Kalula SZ. Drugs and the older person. CME 2007 25(9): 422–425.

Ross K. Driving assessment in the older person. CME 2007; 25(9): 441–442.

Chapter in Book

Hale WA, Joubert JD, Kalula S, Aging population and chronic illness. In Markle WH, Fisher MA, Smego RA (Eds) Understanding global health. New York: McGraw-Hill, 2007:208–229.

Published conference proceedings

Ferreira, M., Kalula, SZ. ILC South Africa. In: Macleod, R. (Ed) Human rights in an ageing world: perspectives from around the world. London: ILC-UK, 2007: 7–10.

Kalula, SZ, prevention of falls in older persons: Africa case study. A WHO global report on falls among older persons. 2007: 1–31.http://www.who.int/ageing/projects/AFRO.pdf

Aboderin, I. & Ferreira, M. Linking ageing to development agendas in sub-Saharan Africa: Challenges and approaches. World Demographic Association Discussion Paper Series, 2007. Available at www.wdassociation.org

DIVISION OF CLINICAL HAEMATOLOGY

Research papers and refereed articles

Sanz MA, Labopin M, Gorin N-C, de la Rubia J, Arcese W, Meloni G, Bacigalupo A, Alessandrino P, Carreras E, Iriondo A, Novitzky N, Jacobs P, Bandini G, Lo-Coco F, Frassoni F, Rocha V. Hematopoietic stem cell transplantation for adults with acute promyelocytic leukemia in the ATRA era: a survey of the European Cooperative Group for Blood and Marrow Transplantation. 2007;39:461-469.

Novitzky N, Thomas V. Allogeneic stem cell transplantation with T cell-depleted grafts for lymphoproliferative malignancies. Biol Blood Marrow Transplant 2007;13(1)107-115.

HATTER HEART RESEARCH INSTITUTE

Research papers and refereed articles

Ashrafian H, Frenneaux MP, Opie LH. Metabolic mechanisms in heart failure. Circulation 2007; 116:434-448.

Crotti L, Spazzolini C, Schwartz PJ, Shimizu W, Denjoy I, Schulze-Bahr E, Zaklyazminskaya EV, Swan H, Ackerman MJ, Moss AJ, Wilde AAM, Horie M, Brink PA, Insolia R, De Ferrari GM, Crimi G. The common long-QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: Toward a mutation-specific risk stratification. Circulation.2007; 116: 2366-2375.

Deuchar GA, Opie LH, Lecour S. TNFalpha is required to confer protection in an in vivo model of classical ischaemic preconditioning. Life Sci 2007; 80:1686-1691.

Essop MF, Chan WY, Taegtmeyer H. Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress. Febs J 2007; 274:5278-5284.

Essop MF. Cardiac metabolic adaptations in response to chronic hypoxia. J Physiol 2007; 584:715-726.

Minners J, Lacerda L, Yellon DM, Opie LH, McLeod CJ, Sack MN. Diazoxide-induced respiratory inhibition - a putative mitochondrial K(ATP) channel independent mechanism of pharmacological preconditioning. Mol Cell Biochem 2007; 294:11-18.

Opie LH, Lecour S. The red wine hypothesis: from concepts to protective signalling molecules. Eur Heart J 2007; 28:1683-1693.

Opie LH. Clinical update: Metabolic syndrome. Circulation 2007; 115: e32-35.

Puig JG, Marre M, Kokot F, et al. Efficacy of indapamide SR compared with enalapril in elderly hypertensive patients with type 2 diabetes. Am J Hypertens 2007; 20:90-97.

Zungu M, Alcolea MP, Garcia-Palmer FJ, Young ME, Essop MF. Genomic modulation of mitochondrial respiratory genes in the hypertrophied heart reflects adaptive changes in mitochondrial and contractile function. Am J Physiol Heart Circ Physiol 2007; 293:H2819-H2825.

Books

Opie L H, Yellon D M (Editors). Cardiology at the Limits IX. University of Cape Town Press, Stanford Writers, Cape Town, 2007, pages 173.

Opie L H, Yellon D M, Kasuga M (Editors). Diabetes at the Limits III. University of Cape Town Press, Stanford Writers, Cape Town, 2007, pages 113.

Chapters in books

Opie LH. The metabolic syndrome – does it exist?. In: Diabetes at the Limits II. Opie LH, Kasuga M, Yellon DM, eds. University of Cape Town Press, Cape Town. 2007. pp.95 - 100.

Opie LH. Mechanisms of cardiac contraction and relaxation, In: Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. 8th edtion. ,Libby P, Bonow RO, Mann DL, Zipes P, eds, Elsevier Saunders, Philadelphia. 2007. pp

Theses and Dissertations

Zungu M, PhD. Characterization of molecular and functional changes regulating hypoxia-induced right ventricular hypertrophy. (Awarded, 2007)

Lamont K. BSc (Hons). Delineation of a mechanism for resveratrol-induced cardioprotection. (Awarded, December 2007)

DIVISION OF HEPATOLOGY & MRC/UCT LIVER RESEARCH CENTRE

Research papers and refereed articles

Anstey AV, Hift RJ. Liver disease in erythropoietic protoporphyria: insights and implications for management. Gut 2007; 56: 1009-1018.

Chirwa N, mall A, Tyler M, Kavin B, Goldberg P, Krige JEJ, Lotz Z, Kahn D. Biochemical and immunohistochemical characterisation of mucins in 8 cases of colonic disease – a pilot study. S Afr J Surgery 2007; 45(1): 18-23.

Habte HH, Kotwal GJ, Lotz ZE, Tyler MG, Abrahams M, Rodriques J, Kahn D, Mall AS.

Antiviral activity of purified human breast milk mucin. Neonatology (formerly Biology of the

Neonate) 2007; 92: 96-104.

Habte HH, Mall AS, de Beer C, Lotz ZE, Kahn D. The role of crude human saliva and purified salivary MUC5B and MUC7 mucins in the inhibition of human immunodeficiency virus type I in an inhibition assay. Virology Journal 2007; 3: 99, doi: 10.1186/1743-422x-3-99.

Mall AS, Chirwa N, Govender D, Lotz Z, Tyler M, Rodrigues J, Kahn D, Goldberg P. MUC2, MUC5AC and MUC5B in the mucus of a patient with pseudomyxoma peritonei:Biochemical and immunohistochemical study. Pathology International 2007; 57: 537-547.

Mall AS, Tyler M, Lotz Z, Davidson A, Rodrigues J, van der Watt G, Kahn D, Govender D. The characterisation of mucin in a mature ovarian teratoma occurring in an eight year old patient. Int J Med Sci 2007; 4(2): 115-123.

Miura F, Ttakada T, Kawarada Y, Nimura Y, Wada K, Hirota M, Nagino M, Tsuyuguchi T, Mayumi T, and Bornman PC, et al. Flowcharts for the diagnosis and treatment of acute cholangitis and cholecystitis: Tokyo Guidelines. J Hepatobiliary Pancreat Surg 2007; 14: 27-34.

Nicol AJ, Hommes M, Primrose R, Navsaria PH, Krige JEJ. Packing for control of hemorrhage in major liver trauma. World Journal of Surgery 2007; 31: 569-574.

Takada T, Kawarada Y, Nimura Y, Yoshida M, Mayumi T, Sekimoto M, Miura F, Wada K, and Bornman P, et al. Background: Tokyo Guidelines for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat surg 2007; 14: 1-10.

Wada K, Takada T, Kawarada Y, Nimura Y, Miura F, Yoshida M, Mayumi T, Strasberg S, Pitt HA, Gadacz TR, and Bornman PC, et al. Diagnostic criteria and severity assessment of acute cholangitis: Tokyo Guidelines. J Hepatobiliary Pancreat Surg 2007; 14: 52-58.

Watermeyer GA, Shaw JM, Krige JEJ. Gastrointestinal: acute necrotizing esophagitis. J Gastroenterol Hepatol 2007; 22: 1162.

Published abstracts

Lodewijk L, Mullerl E, Mall AS, Spearman W, Kahn D. The effect of liver regeneration on rapamycin pharmacokinetics. Transplant International 2007; 20(Suppl 2): 146-147.

Lodewijk L, Mall AS, Spearman W, Shephard EG, Kahn D. Tacrolimus-pharmacokinetics is impaired in liver regeneration. Transplant International 2007; 20(Suppl 2): 279.

DIVISION OF HYPERTENSION AND NEPHROLOGY

Research papers and refereed articles

Cupido C, Rayner B. Life-threatening angio-oedema and death associated with the ACE inhibitor enalapril. S Afr Med J 2007; 97:244-5.

Lindhorst J, Alexander N, Blignaut J, Rayner B. Differences in hypertension between blacks and whites: an overview. Cardiovasc J S Afr 2007; 18: 241-7.

Payne JR, Dhamrait SS, Gohlke P, Cooper J, Scott RA, Pitsiladis YP, Humphries SE, Rayner B, Montgomery HE. The Impact of ACE Genotype on Serum ACE Activity in a

Black South African Male Population. Ann Hum Genet 2007; 71: 1-7.

Rayner B, Blockman M, Baines D, Trinder Y. A survey of hypertensive practices in two community health centres in Cape Town, South Africa. S Afr Med J April, 2007; 97: 280-284.

Non-peer reviewed articles

Okpechi IG, Pascoe MD, Rayner BL. LEP C538T polymorphism and obesity related phenotypes: an association in black hypertensives. Cardiovasc J Afr, 2007;18: S23-4.

Okpechi IG, Pascoe MD, Swanepoel CR, Barday Z, Rayner BL. The metabolic syndrome and early kidney disease in non-diabetic black South Africans. Diab Vasc Dis Res 2007; 4:S86.

Peter JG, Swanepoel CR. A case report: beware of the rapidly rising creatinine in diabetic patients. CME 2007; 25(1): 40.

Rayner B. ADVANCE in the prevention of cardiovascualr disease in type 2 diabetics. S Afr J Diabetes Vasc Dis 2007; 4: 131-2.

Rayner B. Combination therapy in hypertension. SA Fam Pract 2007; 49: 19-20. Rayner B. When to refer a patient with hypertension. CME 2007; 25:

Rayner BL. A post-authorisation study of irbesartan-based therapy in private practice in South Africa – the ACTIVE Study. SA Cardiology and Stroke; 2007; 1: 46-51.

Rayner BL. Acute saline loading in lean young black and white subjects. Cardiovasc J Afr, 2007;18: S25.

Rayner BL. Drug treatment and compelling indications. Cardiovasc J Afr, 2007;18: S25.

Rayner BL. Hypertension management: a synopsis of the new South African hypertension guidelines for primary care practitioners. MIMS Primary Care Review, 2007.

Rayner BL. Moxonidine, Metabolic Syndrome and the MARRIAGE Study: A Review and Progress Report. http://www.siicsalud.com/dato/dat052/07329000.htm 2007

Swanepoel CR. Chronic kidney disease is a risk factor for cardiovascular disease. S Afr Heart J 2007; 4(3): 36-41.

Swanepoel CR. Predialytic treatment of chronic kidney disease is an important part of management. CME 2007; 25(8): 389-394.

 

Chapters in books

Rayner BL, Charlton K, Lambert V and Derman W. Non-pharmacological prevention and treatment of hypertension. Comprehensive Clinical Nephrology. Feehally, Floege and Johnson (eds): 3rd edition. Mosby Elsevier, Philadelphia, 2007.

 

Published abstracts

Jones ESK, Owen EP, Davidson JS, van der Merwe L, Rayner BL. Association of the R563Q mutation of the epithelial sodium channel with hypertension in 18 kindreds. Cardiovasc J Afr, 2007;18: S17.

 

Letters

Rayner BL, Seedat YK, Milne J, V. Pinkney-Atkinson, Veriava Y. The South African Hypertension Guideline 2006 is evidence-based and not cost-effective – a rebuttal. (Letter) S Afr Med J 2007; 97: 194-5.

Rayner BL. Clinical lessons from an elderly man with amiodarone-induced interstitial lung disease. (Scientific letter) S Afr Med J, 2007; 97: 360-2.

DIVISION OF INFECTIOUS DISEASES AND HIV MEDICINE

Research papers and refereed articles

Bicanic T, Meintjes G, Wood R, Hayes M, Rebe K, Bekker LG, Harrison T. Fungal burden, early fungicidal activity, and outcome in cryptococcal meningitis in antiretroviral-naive or antiretroviral-experienced patients treated with amphotericin B or fluconazole. Clin Infect Dis. 2007 Jul 1;45(1):76-80.

Boulle A, Orrel C, Kaplan R, Van Cutsem G, McNally M, Hilderbrand K, Myer L, Egger M, Coetzee D, Maartens G, Wood R; International Epidemiological Databases to Evaluate Aids in Southern Africa Collaboration. Substitutions due to antiretroviral toxicity or contraindication in the first 3 years of antiretroviral therapy in a large South African cohort. Large South African cohort. Antivir Ther. 2007; 12(5): 753-760.

Breen A, Swartz L, Flisher AJ, Joska JA, Corrigall J, Plaatjies L, McDonald DA. Experience of mental disorder in the context of basic service reforms: The impact on caregiving environments in South Africa. Int J Environ Health Res. 2007 Oct;17(5):327-334.

Charalambous S, Grant A, Day JH, Pemba L, Chaisson RE, Kruger P, Martin D, Wood R, Brink B, Churchyard GJ. Establishing a workplace antiretroviral therapy programme in South Africa. AIDSCARE 2007; 19(1): 34-41.

Connell TG, Shey MS, Seldon R, Rangaka MX, van Cutsem G, Simsova M, Marcekova Z, Sebo P, Curtis N, Diwakar L, Meintjes GA, Leclerc C, Wilkinson RJ, Wilkinson KA. Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector. Clin Vaccine Immunol. 2007 Jul;14(7):847-54.

Harling G, Bekker L-G, Wood R. Cost of a dedicated ART clinic. S Afr Med J. 2007; 97(8):593-596.

Harling G, Orrell C, Wood R. Healthcare utilization of patients accessing an African national treatment program. BMC Health Services Research. 2007; 7: 80.

Harling G, Wood R. The evolving cost of ART in South Africa: Changes in Healthcare Costs with Duration of Therapy for Public Sector Patients. J Acquir Immune Defic Syndr 2007;45 (3):348-54

Henao-Tamayo, M, AP Junqueira-Kipnis, D Ordway, M Gonzales-Juarrero, GR Stewart, DB Young, RJ Wilkinson, RJ Basaraba, and IM Orme. 2007. A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties. Vaccine 2007; 25: 7153-7159.

Jarvis JN, Harrison TS. HIV Associated Cryptococcal Meningitis. AIDS. 2007; 21: 2119-2129.

Jaspan H, Flischer AJ, Myer L, Mathews C, Seebregts C, Berwick JR, Wood R, Bekker LG, Brief Report: Methods for collecting sexual behaviour information from South African Adolescents – a comparison of paper versus personal digital assistance questionnaires. J Adolesc. 2007; 30(2): 353-359.

Johnson, LF, Bekker LG, Dorrington, RE HIV/AIDS vaccination in adolescents would be efficient and practical when vaccine supplies are limited. Vaccine 2007; 25: 7502-7509.

Joska J, Flisher AJ. Needs and services at an in-patient psychotherapy unit. African Journal of Psychiatry August 2007; 10:3.

Kenyon C, Pillay K, Jacobs P. Castleman’s disease and retroviral therapy. Transfusion and Apheresis Science 2007; 37(1): 81-84.

Kenyon C. Academic Health Sector fails in HIV response. S Afr Med J 2007: 97 (5) 310-12.

Lawn SD, Bangani N, Vogt M, Bekker LG, Badri M, Ntobongwana M, Dockrell HM, Wilkinson RJ, Wood R. Utility of interferon- ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa. BMC Infect Dis 2007; 7: 99.

Lawn SD, Edwards D, Wood R. Concurrent drug therapy for tuberculosis and HIV infection: current status and future prospects. Future HIV Ther 2007; 1: 387-398

Lawn SD, French MA. Immune reconstitution disease: recent developments and implications for antiretroviral treatment in resource-limited settings. Curr Opin HIV/AIDS 2007; 2: 339-345.

Lawn SD, Kaplan R, Wood R, Bekker LG. Promoting retention in care: an effective model in an antiretroviral treatment service in South Africa. Clin Infect Dis 2007; 45: 803.

Lawn SD, Lockwood DNJ. Leprosy following initiation of antiretroviral treatment: cause foralarm? BMJ 2007; 334: 217-218.

Lawn SD, Myer L, Badri M, Bekker LG, Wood R. Reply to Ouattara et al.: past history of tuberculosis is not a risk factor for incident tuberculosis during ART in South Africa. AIDS 2007; 21: 388-389.

Lawn SD, Myer L, Bangani N, Vogt M, Wood R. Plasma levels of soluble urokinase-type plasminogen activator receptor (suPAR) and early mortality risk among patients enrolling for antiretroviral treatment in South Africa. BMC Infect Dis 2007; 7: 41.

Lawn SD, Myer L, Bekker LG, Wood R. Early Mortality Among Patients with HIVAssociated Tuberculosis in Africa: Implications for the Time to Initiation of Antiretroviral Treatment. S Afr J HIV Med 2007; 37-39.

Lawn SD, Myer L, Bekker LG, Wood R. Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact within an antiretroviral treatment programme in sub-Saharan Africa. AIDS 2007; 21: 335-341.

Lawn SD, Wood R. CD4 cell count distributions and HIV-associated mortality in Africa. J Infect Dis 2007; 195: 1078-1079.

Lawn SD, Wood R. Hepatic involvement with immune reconstitution disease associated with tuberculosis. AIDS 2007; 21: 2362-2363.

Lawn SD, Wood R. Optimal time to initiate antiretroviral therapy in patients with tuberculosis: there may be more than one right answer. J Acq Imm Def Syndr 2007; 46; 121-123.

Lawn SD, Wood R. When should antiretroviral treatment be started in patients with tuberculosis In South Africa? S Afr Med J 2007; 96: 502-503.

Lawn SD. Immune reconstitution disease associated with parasitic infections following    initiation of antiretroviral therapy. Curr Opin Infect Dis 2007; 20: 482-483.

Lawn SD. Schistosomiasis and immune reconstitution disease. AIDS 2007; 21: 1986-1987.

Lund C, Breen A, Flisher AJ, Swartz L, Joska J, Corrigal J, Kleintjes S, Patel V. Mental health and poverty: A systematic review of the research in low and middle income countries. Journal of Mental Health Policy and Economics 2007; 10 (suppl 1): S26-S27.

Maartens G, Wilkinson RJ. Tuberculosis. Lancet 2007; 370 (9604):2030-43.

Mark P Nicol, Beate Kampmann, Patricia Lawrence, Kathy Wood, Sandy Pienaar, David Pienaar, Brian Eley, Michael Levin, David Beatty, Suzanne T.B. Anderson. Enhanced Anti-Mycobacterial Immunity in Children with Erythema Nodosum and a Positive Tuberculin Skin Test. J Invest Derm 2007; 127(9):2152-2157.

Martineau AR ,Wilkinson KA, Newton SM, Floto RA, Norman AW, Skolimowska K, Davidson RN, Sørensen OE, Kampmann B, Griffiths CJ, Wilkinson RJ Interferon-g and Tumor Necrosis Factor independent Vitamin D inducible human suppression of mycobacteria: the role of cathelicidin LL-37. Journal of Immunology 2007; 178: 7190-7198.

Martineau AR, Honecker FU, Wilkinson RJ and Griffiths CJ. Vitamin D in the treatment of pulmonary tuberculosis. Journal of Steroid Biochemistry and Molecular Biology 2007; 103(3-5): 793-798.

Martineau AR, Newton SM, Wilkinson, KA, Kampmann B, Hall BM, Nawroly N, Packe GE, Davidson RN, Griffiths CJ, Wilkinson RJ Neutrophil-mediated innate immune resistance to mycobacteria. Journal of Clinical Investigation 2007; 117: 1988-1994.

Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, Packe GE, Davidson RN, Eldridge SM, Maunsell ZJ, Rainbow SJ, Berry JL, Griffiths CJ. A single dose of vitamin D enhances immunity to mycobacteria. American Journal of Respiratory and Critical Care Medicine 2007; 176: 208-213.

McIlleron H, Meintjes G, Burman WJ, Maartens G. Complications of antiretroviral therapy in patients with tuberculosis: drug interactions, toxicity, and immune reconstitution inflammatory syndrome. J Infect Dis. 2007 Aug 15;196 Suppl 1:S63-75.

McIlleron H, Watkins ML, Folb PI, Ress SR b Wilkinson RJ Rifampin levels, Interferongamma release and outcome in complicated pulmonary tuberculosis Tuberculosis 2007; 87(6): 557-564.

Mendelson M. The diagnosis of TB in HIV-infected individuals: challenges and future prospects. British Medical Bulletin. 2007; 81-82:149-65.

Mendelson M. What’s in a name? British Medical Journal 2007; 334: 852. Myer L, Morroni C, Rebe K. Prevalence and determinants of fertility intentions of HIVinfected women and men receiving antiretroviral therapy in South Africa. AIDS Patient Care STDS. 2007; 21(4): 278-285.

Nicol MP and Wilkinson RJ Evidence guiding the treatment of children with mycobacterial diseases Clinical Infectious Diseases 2007; 44(8):1065-1066.

Nicol MP, Kampmann B, Lawrence P, Wood K, Pienaar S, Pienaar D, Eley B, Levin M, Beatty D, Anderson STB. Enhanced Anti-Mycobacterial Immunity in Children with Erythema Nodosum and a Positive Tuberculin Skin Test. J Invest Derm 2007; 127(9):2152-2157.

Orrell C, Guy Harling G, Lawn SD, Kaplan R, McNally M, Bekker L-G, Wood R.Conservation of first line antiretroviral treatment regimen where therapeutic options are limited. Antiviral Therapy. 2007; 12: 83-88.

Pepper DJ, Meintjes GA, McIlleron H, Wilkinson RJ. Combined therapy for tuberculosis and HIV-1: the challenge for drug discovery. Drug Discov Today. 2007 Nov;12(21-22):980-9. Epub 2007 Sep 27.

Rangaka MX, Diwakar L, Seldon R, van Cutsem G, Meintjes GA, Morroni C, Mouton P, Shey MS, Maartens G, Wilkinson KA, Wilkinson RJ. Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans. Clin Infect Dis. 2007 Jun 15;44(12):1639-46.

Rangaka MX, Wilkinson KA, Seldon R, Van Cutsem G, Meintjes GA, Morroni C, Mouton P, Diwakar L, Connell TG, Maartens G, Wilkinson RJ. Effect of HIV-1 infection on T-Cellbased and skin test detection of tuberculosis infection. Am J Respir Crit Care Med. 2007 Mar 1;175(5):514-520.

Saranchuk P, Boulle A, Hilderbrand K, Coetzee D, Bedelu M, van Cutsem G, Meintjes G. Evaluation of a diagnostic algorithm for smear-negative pulmonary tuberculosis in HIVinfected adults. S Afr Med J. 2007 Jul;97(7):517-23.

Wood R, Middelkoop K, Myer L, Grant AD, Whitelaw A, Lawn SD, Kaplan G, Heubner R, McIntyre J, Bekker L-G The burden of undiagnosed tuberculosis in an African community with high HIV-prevalence: implications for TB control. Am J Resp Crit Care Med 2007; 175(1): 87-93.

Wiysonge CS, Shey MS, Shang J, Kongnyuy EJ, Brocklehurst P. Vaginal microbicides for preventing mother-to-child transmission of HIV infection – no evidence of an effect or evidence of no effect? S Afr Med J 2007; 97(7): 530-533.

 

Chapter in book

Lawn SD, Griffin GE. Immune response to infection, 2nd Edition. In: Thomlinson S, Heagerty AM, Weetmen AP, Malik R. (Eds) Mechanisms of Disease. Cambridge University Press, 2007

Robin Wood. Large-scale implementation of antiretroviral therapy: Early results from faithbased clinics in South Africa. Health Care in Rural South Africa. Editors Adri Vermeer and Hugo Templeman. 2 nd Edition, VU University Press, Netherlands

Robin Wood. Contributing author. Southern African Handbook of HIV Medicine. Editors Wilson D and Bekker L-G. 2nd Edition, Oxford University Press Southern Africa, Cape Town 2007.

 

Letters

Breen A, Swartz L, Joska J, Flisher AJ, Corrigal J. Adherence to treatment in poorer

countries: a new research direction? Pyschiatr Serv 2007;58(4):567-8

Swartz L, Breen A, Flisher AJ, Joska J, Corrigall J, Plaatjies L, McDonald DA. Contextual

challenges to adherence to psychiatric treatment in poorer countries: a possible new research direction”. Psychiatric Services 2007; Apr;58(4):567-568. (Letter to the editor)

DIVISION OF LIPIDOLOGY

Research papers and refereed articles

Abera AB, Marais AD, Raal FJ, Leisegang F, Jones S, George P, Henderson HE. Autosomal recessive hypercholesterolaemia: Discrimination of ARH protein and LDLR function in the homozygous FH phenotype. Clin Chim Acta 2007;378:33-37.

Blackhurst DM, Wolmarans KH, Marais AD. Wine dilates the brachial artery but does not increase flow-mediated dilatation over two hours. S Afr J Enol Vitic 2007;28(1):11-

EPG Mansvelt Fourie E, Blackhurst D, Kotze T, Stofberg H, van der Merwe S, Kotze MJ, van Velden DP. The influence of a Mediterranean diet with and without red wine on the haemostatic and inflammatory parameters of subjects with the metabolic syndrome. S Afr J Enol Vitic 2007;28(1):37-43.

Hooper AJ, Marais AD, Tanyanyiwa DM, Burnett JR. The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population. Atherosclerosis 2007;193:455-8.

Stein EA, Marais AD, Docubu J, Farnier M, Gavish D, Hauner H, Kaplan AJ, le Maulf F, Melinzinkova H. Comparison of short-term renal effects and efficacy of rosuvastatin 40 mg and simvastatin 80 mg, followed by assessment of long-term renal effects of rosuvastatin 40 mg, in patients with dyslipidemia. Journal of Clinical Lipidology (2007) 1, 287–299

Van Velden DP, van der Merwe S, Fourie E, Kidd M, Blackhurst DM, Kotze MJ, Mansvlet EPG. The short-term influence of a Mediterranean-type diet and mild exercise with and without red wine on patients with the metabolic syndrome. S Afr J Enol Vitic 2007;28(1)44-49.

 

DIVISION OF NEUROLOGY

Research papers and refereed articles

Bateman K, Schinkel M, Little F, Liebenberg L, Vincent A, Heckmann J. Incidence of seropositive myasthenia gravis in Cape Town and South Africa. S Afr Med J 2007; 97(10):959-962.

Heckmann J. Owen E, Little F. Myasthenia gravis in South Africa: racial differences in clinical manifestations. Neuromuscular Dis. 2007. doi : 10. 1016/j. nmd. 2007. 07. 002.

Mead S, Webb T, Campbell T, Beck J, Linehan J, Rutherfoord S, Joiner S, Wadsworth J, Heckmann J, Wroe S, Doey L, King A, Collinge J. Inherited prion disease with Soctapeptide repeat insertion mutation in PRNP phenotype modification by repeat length and codon 129 polymorphism. Neurology 2007; 69: 730-736.

Tipping B, de Villiers L, Wainwright H, Candy S, Bryer A. Stroke in patients with human immunodeficiency virus infection. J. Neurol. Neurosurg. Psychiatry. 2007; 78:1320-1324.

Non peer-reviewed articles

Kies B. Convulsions and Epilepsy. MIMS Primary Care Treatment Guidelines for nurse, practitioners and community service doctors. 2007, pg 204-206.

DIVISION OF PHARMACOLOGY

Research papers and refereed articles

Arens J, Barnes K, Crowley N, martens G. Treating AIDS-associated cerebral toxoplasmosis: pyrimethamine plus sulfadiazine compared with cotrimoxazole, and outcome with adjunctive glucocorticoids. S Afr Med J 2007; 97: 956-958.

Barnes KI, Lindegardh N, Ogundahunsi O, Olliaro P, Plowe CV, Randrianarivelojosia M, Ghotosho GO, Watkins WM, Sibley CH, White NJ. World antimalarial resistance network (WARN) IV: clinical pharmacology. Malaria J 2007; 6: 122.

Barnes KI. Rolling back malaria in Africa. S Afr Med J 2007; 97(1): 36-37.

Boulle A, Orrell C, Kaplan R, McNally M, van Cutsem G, Hilderbrand K, Myer L, Egger M, Coetzee D, Maartens G, Wood R. Substitutions due to antiretroviral toxicity or contraindication in the first three years of ART in a large South African cohort. Antiviral Therapy 2007; 12: 753-760.

Clarkson C, Madikane VE, Hansen HS, Smith PJ, Sim E, Jaroszewski JW. HPLC-SPENMR characterization of sesquiterpenoids in an antimycobacterial fracdtion from Warburgia salutaris. Planta Med 2007; 73(6): 578-584.

Diacon AH, Patientia RF, Venter A, van helden PD, Smith PJ, McIlleron H, Maritz JS, Donald PR. Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears. Antimicrob agents chemother 2007; 51(8)): 2994-2996.

Gabriels GA, McIlleron H, Smith PJ, Folb PI, Fourie PB. Modification to improve efficiency of sampling schedules for BA/BE testing of FDC anti-tuberculosis drugs. Int J Tuberc Lung Dis 2007; 11(2): 181-188.

Hiss DC, Gabriels GA, Folb PI. Combination of tunicamycin with anticancer drugs synergistically enhances their toxicity in multidrug-resistant human ovarian cystadenocarcinoma cells. Cancer Cell International 2007; 7: 5, doi: 10.1186/1475-2867-7-5.

Kamatou GPP, Viljoen AM, van Heerden FR, Seaman T, van Vuuren SF, van Zyl RL. Antibacterial and antimycobacterial activities of South African indigenous Salvia species and isolated compounds from S. chamelaeagnea. S Afr J Botany 2007; 73: 552-557.

Maartens G, Boulle A. CD4 T-cell responses to combination antiretroviral therapy. Lancet 2007 370: 366-368 [invited comment]

Maartens G, Wilkinson RJ. Tuberculosis. Lancet Published online August 21, 2007, doi. 10.1016/S0140-6736(07)61262-8. [invited seminar]

Madikane VE, Bhakta S, Russell AJ, Westwood I, Campbell WB, Claridge TDW, Elisha GB, Davies SG, Smith P, Sim E. Inhibition of arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris. Bioorganic & Medicinal Chemistry 2007; 15(10): 3579-3586.

McIlleron H, Meintjes G, Burman WJ, Maartens G. Complications of antiretroviral therapy  in patients with tuberculosis – drug interactions, toxicity and immune reconstitution inflammatory syndrome. Journal of Infectious Diseases 2007; 196: S63-75.

McIlleron H, Norman J, Kanyok TP, Fourie PB, Horton J, Smith PJ. Elevated gatifloxacin and reduced rifampicin concentrations in a single dose interaction study amongst healthy volunteers. Journal of Antimicrobial Chemotherapy 2007; 60(6): 1398-1401.

McIlleron H, Watkins ML, Folb PI, Ress SR, Wilkinson PJ. Rifampin levels, interferongamma release and outcome in complicated pulmonary tuberculosis. Tuberculosis 2007; 87: 557-564.

Mehta U, Durrheim D, Mabuza A, Blumberg L, Allen E, Barnes KI. Malaria pharmacovigilance in Africa: lessons from a pilot project in Mpumalanga Province, South Africa. Drug Safety 2007; 30(10): 899-910.

Mehta U, durrheim DN, Blumberg L, Donohue S, Hansford F, Mabuza A, Kruger P, Gumede JK, Immelman E, Sanchez Canal A, Hugo JJ, Swart G, Barnes KI. Malaria deaths as sentinel events to monitor healthcare delivery and antimalarial drug safety. Trop Med Int Health 2007; 12(5): 617-628.

Mehta U, Maartens G. Is it safe to switch between efavirenz and nevirapine in the event of toxicity? A review of the evidence. Lance Infectious Diseases 2007; 7: 733-738.

Mells EJ, Nachega JB, Guyatt G, Buchan I, Orbinski J, Attaran A, Singh S, Rachlis B, Wu P, Thabane L, Wilson K, Bangsberg DR. Adherence to antiretroviral therapy in Africa and North America: a meta analysis. Journal of American Medical Association 2006; 296(6): 679-690. too late for 2006 report.

Mohammed A, Ehrlich R, Myer L, Wood R, Cilliers F, Maartens G. Randomised controlled trial of isoniazid preventive therapy, directly observed by patient-nominated supervisors, in South African adults with advanced HIV disease. Int J Tubercul Lung Dis 2007; 11: 1114-1120.

Nachega JB, Hislop M, Dowdy DW, Chaisson RE, Regensberg L, Maaqrtens G. Adherence to non-nucleoside reverse transcriptase inhibitor-based HIV therapy and virologic outcomes. Annals Int Med 2007; 146(8): 564-573.

Pepper DJ, Meintjes GA, McIlleron H, Wilkinson RJ. Combined therapy for tuberculosis and HIV-1: the challenge for drug discovery. Drug Discovery Today 2007; 12(21-22): 980-989.

Pillay P, Vleggar R, Lategan CA, Maharaj VJ, Smith PJ. Isolation and identification of antiplasmodial sesquiterpene lactones from Oncosiphon piluliferum. J Ethnopharmacology 2007: 112: 71-76.

Pillay P, Vleggar R, Maharaj VJ, Smith PJ, Lategan CA, Chouteau F, Chibale K. Antiplasmodial hirsutinolides from Vernonia staehelinoides and their utilization towards a novel simplified pharmacophore. Phytochemistry 2007; 68: 1200-1205.

Price RN, Dorsey G, Ashley EA, Barnes KI, Baird JK, d’Alessandro U, Guerin PJ, Laufer MK, Naidoo I, Nosten F, Olliaro P, Plowe CV, Ringwald P, Sibley CH, Stepniewska K, White NJ. World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs. Malaria Journal 2007; 6: 119.

Rangaka MX, Diwakar L, Seldon R, van Cutsem G, Meintjes GA, Morroni C, Mouton P, Shey MS, Maartens G, Wilkinson KA, Wilkinson RJ. Clinical, immunological and epidemiological importance of anti-tuberculosis T cell responses in HIV infected Africans. Clinical Infectious Diseases 2007; 44: 1639-1646.

Rangaka MX, Wilkinson KA, Seldon R, van Custem G, Meintjes GA, Mouton P, Morroni C, Goemaere E, Korrakuti L, Connell T, Maartens G, Wilkinson RJ. Interferon gamma based immunodiagnosis of tuberculosis infection appears relatively unimpaired by HIV infection but agrees only moderately with skin testing. Am J Respir Crit Care Med 2007; 175(5): 514-520.

Rautenbach M, Vlok M, Stander M, Hoppe HC. Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis. Biochimica et Biophysica Acta Biomembranes 2007; 1768: 1488-1497.

Rayner B, Blockman M, Baines D, Trinder Y. A survey of hypertensive practices at two community health centres in Cape Town. S Afr Med J 2007; 97: 280-284.

Ren Y, Nuttall JJ, Egbers C, Eley BS, Meyers TM, Smith PJ, Maartens G, McIlleron HM. High prevalence of subtherapeutic plasma concentrations of efavirenz in children. J Acquir Immune Defic Syndrome 2007; 45(2): 133-136.

Sekhoacha M, Campbell B, Seaman T, Smith P. Isolation of an antiplasmodially active sesquiterpene lactone from South African indigenous medicine plant Warbugia salutaris. S afr J Botany 2007; 73(2): 311-312.

Sharp BL, Kleinschmidt I, Streat E, Maharaj R, Barnes KI, Durrheim DN, Ridl FC, Morris N, Seocharan I, Kunene S, La Grange JJ, Mthembu JD, Maartens G, Martin CL, Barreto A. Seven years of regional malaria control collaboration – Mozambique, South Africa and Swaziland. Am J Trop Med Hyg 2007; 76(1): 42-47.

Sibley CH, Barnes KI, Plowe CV. The rationale and plan for creating a World Antimalarial Resistance Network (WARN). Malaria J 2007; 6: 118.

Smythe WA, Joiner KA, Hoppe HC. Actin is required for endocytic trafficking in the malaria parasite Plasmodium falciparum. Cellular Microbiology [epub ahead of print]

Spinewine A, Swine C, Dhillon S, Lambert P, Nachega JB, Wilmote L, Tulkens PM. Impact of a collaborative approach on the quality of prescribing for geriatric inpatients. A randomized controlled trial. J Am Geriatric Soc 2007; 55: 658-665.

Van Wyk AWW, Lobb KA, Caira M, Hoppe HC, Davies-Coleman MT. Transformations of manool. Novel tr- and tetracyclic norditerpenoids with in vitro activity against Plasmodium falciparum. J Natural Products 2007; 70: 1253-1258.

Non-peer reviewed articles

Barnes KI, Talmud J. Are “atypical” antipsychotics safer than conventional antipsychotics? CME 2007; 25(5): 245-247.

Blockman M. Antimicrobial prophylaxis in surgery. CME 2007; 25(7): 338-339.

Gounden R, Blockman M. Metformin and lactic acidosis. CME 2007; 25(8): 401-402.

Gounden r, Blockman M. Systemic antimicrobials and the eye. CME 2007; 25(10): 497- 498.

Kredo T, Blockman M. Coke, tik and “E” – managing psychomotor-stimulant intoxication. CME 2007; 25(3): 144-146.

Kredo T, Blocvkman M. Hypertension in the elderly. CME 2007; 25(9): 444-446.

Sinxadi P, Maartens G. Drug-induced haemolytic anaemia. CME 2007; 25(6): 286-288.

Sinxadi P, McIlleron H. Principles of dosing in young children. CME 2007; 25(4): 192-193.

Swart A, Blockman M. Principles of using medication in breast-feeding mothers. CME 2007; 25(1): 38-39.

Van der Walt JS, Maartens G. Drug-drug interactions in oncology: implications for general practice. CME 2007; 25(2): 81-84.

DIVISION OF PULMONOLOGY

Research papers and refereed articles

Barnes NC, Jacques L, Goldfrad C, Bateman ED. Initiation of maintenance treatment withsalmeterol/ fluticasone propionate 50/100μg bd versus fluticasone propionate 100μg bd alone in patients with persistent asthma: Integrated analysis of four randomized trials. Respiratory Medicine, 2007; 101: 2358-2365.

Bateman ED, Bousquet J, Busse WW, Clark TJH, Pedersen SE on behalf of the GOAL Investigators Group. The correlation between asthma control and health status: the GOAL study. European Respiratory Journal, 2007;29:56-62.

Bateman ED, Clark TJH, Frith L, Bousquet J, Busse WW, Pedersen SE for the GOAL Investigators Group. Rate of response of individual asthma control measures varies and may overestimate asthma control. J Asthma 2007, 44: 1-7.

Bateman ED, Jithoo A. Asthma and Allergy - A Global Perspective. Allergy 2007; 62:213-215.

Bheekie A, Buskens I, Allen S, English R, Mayers P, Fairall L, Majara B, Bateman ED, Zwarenstein M, Bachmann M. The Practical Approach to Lung Health in South Africa PALSA) intervention: respiratory guideline implementation for nurse trainers. Int Nurs Rev 2006; 53: 261-268. TOO LATE FOR 2006 COUNT

Boulet L-P, Bateman ED, Voves R, Müller T, Wolf S, Engelstätter R. A randomised study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma. Respiratory Medicine 2007; 101: 1677-1686.

Canonica GW, Baena-Cagnani CE, Bousquet J, Bousquet PJ, Lockey RF, Malling H, Passalacqua G, Potter P, Valovirta E. Recommendations for standardization of clinical trials with Allergen Specific Immunotherapy for respiratory allergy – A statement of a World Allergy Organization (WAO) taskforce. Allergy 2007; 62: 317-324.

den Boon S, van Lill SW, Borgdorff MW, Enarson DA, Verwer S, Bateman ED, Irusen E, Lombard CJ, White NW, de Villiers C, Beyers N. High prevalence of tuberculosis in previously treated patients, Cape Town, South Africa. Emerg Infect Dis 2007; 13: 1189-94.

Den Boon S, Verver S, Marais BJ, Enarson DA, Lombard CJ, Bateman ED, Irusen E, Jithoo A, Gie RP, Borgdorff MW, Beyers N. Association between passive smoking and infection with Mycobacterium tuberculosis in children. Pediatrics 2007; 119: 734-739.

den Boon S, White NW, van Lill SW, Borgdorff MW, Verver S, Lombard CJ, Bateman ED, Irusen E, Enarson DA, Beyers N. An evaluation of symptom and chest radiographic screening in tuberculosis prevalence surveys. International Journal of Tuberculosis and Lung Disease. 2006; 10: 876-82. TOO LATE FOR 2006 COUNT

Dheda K, Chang JS, Huggett JF, Kim LU, Johnson MA, Zumla A, Rook GA. The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA  encoding the antagonistic splice variant, IL-4delta2, is not. Tuberculosis (Edinb). 2007 May; 87 (3): 237-41.

Dheda K, Pooran A, Pai M, Miller RF, Lesley K, Booth HL, Scott GM, Akbar AN, Zumla A, Rook GA. Interpretation of Mycobacterium tuberculosis antigen-specific IFN-gamma release assays (T-SPOT.TB) and factors that may modulate test results. J Infect. 2007 Aug; 55(2):169-73.

English RG, Fairall L, Bateman ED. Keeping Allergy on the Agenda: Integrated guidelines for respiratory disease in developing countries. Allergy 2007; 62:224-229.

Feldman C, Brink AJ, Richards GA, Maartens G, Bateman ED, for working group of the South African Thoracic Society. Management of community-acquired pneumonia in adults. S Afr Med J, 2007; 97: 1295-1306.

Green RJ, Potter PC. Antibiotic allergy in the intensive care unit. Curr Allergy Clin Immunol 2007; 20(4): 130-134.

Green RJ, Zar HR, Bateman ED. Asthma: Is survival good enough? S Afr Med J 2007; 97:172-174.

Lala S, Dheda K, Chang JS, Huggett JF, Kim LU, Johnson MA, Rook GA, Keshav S, Zumla A. The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis. BMC Infect Dis. 2007 Aug 16; 7: 96.

Lalloo U, Ainslie G, Wong M, Abdool-Gaffar S, Irusen E et al. Guidelines for the management of chronic asthma in adolescents and adults. SA Fam Pract 2007; 49: 19-31.

Mash R, Ainslie G, Irusen E, Mayers P & Bheekie A. The dissemination and implementation of national asthma guidelines in South Africa: the use of outcome mapping. SA Fam Pract 2007; 49: 5-8.

Pai M, Dheda K, Cunningham J, Scano F, O'Brien R. T-cell assays for the diagnosis of latent tuberculosis infection: moving the research agenda forward. Lancet Infect Dis. 2007 Jun; 7 (6): 428-38.

Pai M, Mohan A, Dheda K, Leung CC, Yew WW, Christopher DJ, Sharma SK. Lethal interaction: the colliding epidemics of tobacco and tuberculosis. Expert Rev Anti Infect Ther. 2007 Jun; 5(3):385-91.

Parham KL, Roberts A, Thomas A, Würzner R, Henderson HE, Potter PC, et al. Prevalence of mutations leading to complete C6 deficiency (C6Q0) in the Western Cape, South Africa and detection of novel mutations leading to C6Q0 in an Irish family. Mol Immunol. 2007;44:2756-2760.

Pedersen SE, Bateman ED, Bousquet J, Busse WW, Yoxall S, Clark TJ, Gaining Optimal Asthma controL Steering Committee and Investigators. Determinants of response to fluticasone propionate and salmeterol/fluticasone propionate combination in the Gaining Optimal Asthma ControL study. Journal of Allergy and Clinical Immunology, 2007; 170: 1036-42.

Potter PC. Allergies and asthma in Southern Africa: an update. International Journal on Immunorehabilitation 2007; 9(1): 37-38.

Potter PC. Investigating adverse reactions to sulphites and benzoates in patients with chronic urticaria and angioedema. International Journal on Immunorehabilitation 2007; 9(1): 31-32.

Spencer S, Mayer B, Bendall KL, Bateman ED. Validation of a guideline-based composite outcome assessment tool for asthma control. Respiratory Research 2007; 8: 26 doi:10.1186/1465-9921-8-26.

Van Zyl-Smit R, Burch V, Willcox P. The need for appropriate critical care service provision at non-tertiary hospitals in South Africa. S Afr Med J 2007 97; 268-272

Woodcock AA, Bagdonas A, Boonsawat W, Gibbs MR, Bousquet J, Bateman ED on behalf of the GOAL Steering Committee & Investigators. Improvement in asthma endpoints when aiming for total control: salmeterol/fluticasone propionate and fluticasone propionate alone. Primary Care Respiratory Journal 2007; 16: 155-161.

Potter PC. Trends in Beta-2-Agonist Therapy. Allergy Clin Immunol Int – J World Allergy Org 2007; 19(4): 155-158.

Canonica GW, Passalacqua G, Lockey RF, Pawankar R, Potter P. Current status of allergen immunotherapy around the globe: Four commentaries. Allergy Clin Immunol Int – J World Allergy Org, 2007; 19(3): 117-120.

Potter PC. Investigation and diagnosis of life threatening allergies in childhood. South African Journal of Child Health July 2007; 1(2): 87-92.

Potter PC. Overview of the indigenous allergies of South Africa. Current Allergy & Clinical Immunology, Nov 2007; 4(26): 174-176.

Prescott RA, Potter PC. Immunochemical characterisation of grass pollen allergens in South Africa. Current Allergy & Clinical Immunology, Nov 2007; 4(26): 189-193.

Editorial

Potter PC. The future direction of Allergology in South Africa. Current Allergy & Clinical Immunology, Nov 2007; 4(26): 170-172.

Non-peer reviewed publication

PC Potter. Sublingual immunotherapy in allergic rhinitis and asthma: an update 2007. The Specialist Forum, February 2007: 16-24.

Potter PC. 40 years after the discovery of the IgE molecule: IgE in the South African context. Specialist Forum, Aug 2007; 7(8): 59-62.

Potter PC. Editorial: New developments of allergy in the Republic of South Africa. PedMed, September 2007.

Potter PC. Eczema in children and adults. MIMS Primary Care. 2007, 1: 44-46.

Published abstracts

Bateman ED, Nelson H, Beasley R, Bousquet J, Yancey S, Kral K, Sutton L, Dorinsky P. Incidence of asthma-related hospitalizations with the addition of salmeterol to an ICS in subjects with asthma: a meta-analysis. Eur Respir J 2007; P2128.

Bateman ED. Experience of asthma management in South Africa. Int J Tuberc Lung Dis 2007; 11:S15.

Condos R, Huie M.L, Dawson R, Ress S, Brauns C, Tseng C.H, Weiden M, Bateman E, Rom R.N. Immunomodulation with pharmocologic IFN-y and its effect on the lung-specific immune response in pulmonary TB. Proc Am Thorac Soc 2007; 175: A821.

Cowie R, Manns B, Bateman ED, den Boon S, Beyers N. Chest X-ray screening and treatment of inactive pulmonary tuberculosis in a high-incidence country. Int J Tuberc Lung Dis 2007; 11:S102.

Dawson R, Condos R, Lucke W, Tseng C.H, Ress S, Evreva M, Bateman E, Rom W.N. Adherence to novel immunotheraphy for tuberculosis in South Africa. Proc Am Thorac Soc 2007; 175: A415.

Fairall L, Bachmann M, Zwarenstein M, Majara B, van Rensburg D, Bateman E, Chapman R. Cost-effectiveness of educational outreach on respiratory diseases in primary care nurses. Int J Tuberc Lung Dis 2007; 11:S144.

Hoshino Y, Hoshino S, Dawson R, Ress S, Bateman E, Rom W.N, Weiden M.D. Adenosine deaminase that acts on RNA-1 (ADRI1) is an innate immune mediator inhibiting HIV-1 replication and increasing HIV-1 mutation after aerosolized. Proc Am Thorac Soc 2007; 175: A100.

Jithoo A, Bateman E.D, White N.W, Lombard C.J, Enarson D.A, Burney P.G.J, Irusen E, Beyers N. The relationship between cannabis and tuberculosis: A population study in a high tuberculosis prevalence area in South Africa. Proc Am Thorac Soc 2007; 175: A777.

Jithoo A, Bateman ED, White N, Lombard C, Beyers N, Burney P, Vollmer W, Buist S. Risk factors for COPD in South Africa: Results from the BOLD Study. Eur Respir J 2007; E1916.

Jithoo A, Bateman ED, White N, Lombard CJ, Beyers N, Burney PGJ, Vollmer W, Buist S. Smoking (including cannabis) and tuberculosis as risk factors for COPD. Int J Tuberc Lung Dis 2007; 11:S8.

Patrawalla A, Huie M, Condos R. Dawson R, Ress S, Bateman E, Braun C, Rom W. Expression of osteopontin (OPN) and matrix metalloproteinas-9 (MMP-9) in cavitary tuberculosis (TB) treated with DOTS Plus interferon-gamma (IFN) or DOTS alone. Proc Am Thorac Soc 2007; 175 : A100.

Van Schalkwyk EM, Lombard C, Beyers N, Bateman ED, Irusen EM. Sensitization to individual allergens and bronchial responsiveness in you adults in Cape Town. Eur Respir J 2007; P3708.

Nurse B, Motala C, Brown N, Potter P. Raised house dust mite-stimulated IL13/IFNg  release: Association with allergen-sensitisation rather than atopic disease. Current Allergy & Clinical Immunology, March 2007, 20(1): 42.

Orren A, Garred P, Thomas AD, Prescott R, Potter PC, Morgan BP. Studies of Mannan Binding Lectin (MBL) serum levels and genotypes in South African patients with complete complement component 6 deficiency (C6Q0) and with or without a history of Neisseria Meningitidis infections. Mol Immunol, 2007; 44: 3996.

Potter PC, Raap U. Levocetirizine is superior to Desloratadine in improving symptoms of chronic idiopathic urticaria: a randomised double blind clinical trial. Proceedings: American College of Allergy and Clinical Immunology Congress, Texas, 2007.

DIVISION OF RHEUMATOLOGY

Research papers and refereed articles

Rosenberg L, Zhang Y, Constant D, Cooper D, Kalla AA, Micklesfield L, Hoffman M. Bone status after cessation of use of injectable progestin contraceptives. Contraception 2007;76(6):425-31

Published abstracts

Potts J, Kalla AA. Psoriatic arthropathy at Ggroote Sschuur hospital, South Africa. Clinical Rheumatol, 26 (4): 465-662; 2007

Kalla AA, Gunter R, Potts J, Ress S, Keraan M. Comparison of autoantibodies in systemic auto-immune diseases. Clinical Rheumatol 2007; 26(4): 465-662.

Kalla AA. 0 steoporosis in Africa. Clinical Rheumatol 2007; 26(4): 465-662.