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Nephrology & Hypertension

Renal Unit Publications

  1. Ikechi Okpechi, Charles Swanepoel, Maureen Duffield, Bonginkosi Mahala, Nicola Wearne, Stella Alagbe, Zunaid Barday, Craig Arendse, Brian Rayner. Patterns of renal disease in Cape Town South Africa: a 10-year review of a single-centre renal biopsy database. Nephrol Dial Transplant 2010
  2. Okpechi IG, Rayner BL, Swanepoel CR. Nephrotic Syndrome in Adult Black South Africans: HIVAN as the main culprit. J Natl Med Assoc.  2010; 102: 1193-7.
  3. Rayner B, Ramesar R, Steyn K, Levitt N, Lombard C, Charlton K. G-protein-coupled receptor kinase 4 (GRK-4) polymorphisms predict blood pressure response to dietary modification in black patients with mild to moderate hypertension. J Hum Hypertens 2011; 26: 334-9.
  4. Okpechi IG, Schoeman HS, Longo-Mbenza B, Oke DA, Kingue S, Nkoua JL, Rayner BL. Achieving blood preSsure goals sTudy in uncontrolled hypeRtensive pAtients treated with a fixed-dose combination of ramipriL/hydrochlorothiazide: the ASTRAL study. Cardiovasc J Afr 2011; 22: 79-84.
  5. James M, Dyer R, Rayner B. A modern look at hypertension and anaesthesia. S Afr J Anaesth Analg 2011;17(2):168-173
  6. IG Okpechi, BL Rayner. ‘Impact of recent landmark clinical trials on hypertension treatment’ Clin Invest 2011; 1(8) 1141 – 1154
  7. Rayner B. Hypertension: detection and management in South Africa. Nephron 2010; 414: c269-c273 (Epub ahead of print)
  8. Tiffin T, Meintjies A, Ramesar R, Bajic V, Rayner B. Computational Analysis of Candidate Disease Genes and Variants for Salt-Sensitive Hypertension in Indigenous Southern Africans. PLoS One 2010; 5(9): e12989 
  9. Rayner B, Musekiwa A, Lombard C, Ramesar R.The A142V polymorphism of the G protein-coupled receptor kinase 4 gene predicts natriuretic response to saline challenge in young normotensive lean Black and White South African men. Nephrology Reviews 2011; 3: e9
  10. Wearne N, Swanepoel CR, Boulle A, Duffield MS, Rayner BL. The spectrum of renal histologies seen in HIV with outcomes, prognostic indicators, and clinical correlations. Nephrol Dial Transplant 2012;27(11):4109-18
  11. Seedat YK, Rayner BL. South African Hypertension Guideline 2011. S Afr Med J 2012; 101: 59-83.
  12. Okpechi I, Swanepoel CR, Tiffin N, Duffield M, Rayner B. Clinicopathological insights into lupus nephritis in South Africans: A study of 251 patients. Lupus 2012; 21;1017-24
  13. Freercks R, Swanepoel C, Carrara H, Moosa S, Lachman A, Rayner B. Vascular calcification in South African dialysis patients: ethnic variation, prevalence, detection and haemodynamic correlates. Nephrology 2012;17(7): 607-15.
  14. Jones ES, Owen EP, Rayner BL. The Association of the R563Q Genotype of the ENaC with Phenotypic Variation in Southern Africa. Am J Hypertens 2012; 25(12): 1286-91
  15. Okpechi IG, Rayner BL, Swanepoel CR. Peritoneal dialysis in Cape Town, South Africa. Perit Dial Int 2012; 32(3): 254-60.
  16. Rayner BL. The young hypertensive patient. SA Family Practice 2012; 54: S29-S30.
  17. Seedat YK, Rayner BL. The Abridged South African Hypertension Guideline 2011. SA Family Practice 2012; 54: S4-S8 
  18. Okpechi I, Olubenga O, Rayner B, Swanepoel CR. Kidney disease in elderly South Africans. Clin Nephrol 2013; 79: 269-76.
  19. Okechukwu S Ogah, Brian L Rayner. Recent advances in hypertension in sub-Saharan Africa. Heart doi:10.1136/heartjnl-2012-303227
  20. Rosansky SJ, Cancarini G, Clark W, Eggers P, Germaine M, Glassock R, Goldfarb D, Harris D, Hwang S-J, Imperial EB, Johansen KL, Kalantar-Zadeh K, Moist LM, Rayner B, Steiner R, Zuo L. Dialysis Initiation: What's the Rush? Seminars in dialysis. Article first published online: 19 SEP 2013 | DOI: 10.1111/sdi.12134
  21. Bobrow K, Brennan T, Springer D, Levitt NS, Rayner B, Namane M, Yu LM, Tarassenko L, Farmer A. Efficacy of a text messaging (SMS) based intervention for adults with hypertension: protocol for the StAR randomised controlled trial.(SMS Text-message Adherence suppoRt trial) BMC Public Health 2014 Jan 11;14(1):28. [Epub ahead of print]
  22. Moholisa RR, Rayner BR, Patricia Owen E, Schwager SL, Stark JS, Badri M, Cupido CL, Sturrock ED. Association of B2 receptor polymorphisms and ACE activity with ACE inhibitor-induced angioedema in black and mixed-race South Africans. J Clin Hypertens (Greenwich). 2013; 15(6): 413-9.
  23. Nel D, Rayner B. HIV vasculopathy of the renal artery manifesting as severe hypertension in a young female: case report and review. Vascular Disease Management 2011; 8: E40-44.
  24. Freercks RJ, Swanepool CR, Turest-Swartz KL, Carrara HR, El Moosa S, Lachman AS, Rayner BL. Vascular calcification is not associated with increased ambulatory central aortic systolic pressure in prevalent dialysis patients. Cardiovasc J Afr 2014; 25(1):4-8. doi: 10.5830/CVJA-2013-081.
  25. Borkum M, Wearne N, Alfred A, Dave JA, Levitt NS, Rayner B. Ambulatory blood pressure profiles in a subset of HIV-positive patients pre and post antiretroviral therapy. Cardiovasc J Afr. 2014; 25(4):153-7. doi: 10.5830/CVJA-2014-029.
  26. Okpechi IG, Dlamini TA, Duffield M, Rayner BL, Moturi G, Swanepoel CR. Outcome of Patients with Primary Immune-Complex Type Mesangiocapillary Glomerulonephritis (MCGN) in Cape Town South Africa. PloS one. 2014;9(11):e113302.
  27. Hypertension guideline working group: YK Seedat, BL Rayner, Yosuf Veriava. South African hypertension practice guideline. Cardiovasc J Afr 2014; 28: 288-94.
  28. Jones ESW, Rayner BL. The importance of guidelines. Cardiovasc J Afr 2014; 28: 296-7.
  29. Rayner, B, Ramesar R. The Importance of G Protein-Coupled Receptor Kinase 4 (GRK4) in Pathogenesis of Salt Sensitivity, Salt Sensitive Hypertension and Response to Antihypertensive Treatment. Review. J. Mol. Sci. 2015, 16(3), 5741-5749.
  30. Jones E, Rayner B. Hypertension, End Stage Renal Disease and Mesangiocapillary Glomerulonephritis in Methamphetamine Users. S Afr Med J 2015; 2015;105(3):199-201.
  31. Folt DA, Evans KL, Brahmandam S, He W, Brewster PS, Yu S, Murphy TP, Cutlip DE, Dworkin LD, Jamerson K, Henrich W, Kalra PA, Tobe S, Thomson K, Holden A, Rayner BL, Grinfeld L, Haller ST, Cooper CJ. Regional and physician specialty-associated variations in the medical management of atherosclerotic renal-artery stenosis. J Am Soc Hypertens. 2015;9(6):443-52
  32. Charle Viljoen, Patryk Szymanski, Naeem Osman, Kristin Lorenc Henning, Paul Scholtz, Brian Rayner, Nadraj Naidoo. Intimomedial mucoid degeneration causing aortic and renal artery aneurysms in a young adult. CVJA in press
  33. J. David Spence, Brian L. Rayner. J Curve and Cuff Artefact, and Diagnostic Inertia in Resistant Hypertension. Hypertension. 2015; 67:32-33.
  34. Kirsten Bobrow, Andrew J Farmer DM, David Springer, Milensu Shanyinde, Ly-Mee Yu, Thomas Brennan, Brian Rayner, Mosedi Namane, Krisela Steyn, Lionel Tarassenko, Naomi Levitt. Treatment adherence support for high blood pressure delivered via mobile phone text messaging (StAR): a single-blind, randomized trial. Circulation 2016 (in press)
  35. Dandara C, Huzair F, Borda-Rodriguez A, Chirikure S, Okpechi I, Warnich L, Masimirembwa C. H3Africa and the African Life Sciences Ecosystem: Building Sustainable Innovation. OMICS. 2014 Dec;18(12):733-9.
  36. Chukwuonye II, Onyeonoro UU, Chuku A, Okpechi IG, Ukegbu AU, Madukwe OO, Akhiemien MO, Okafor GOC, Ezeani I, Ogah OS. Correlates of obesity indices and systemic arterial hypertension in adult Nigerians: a community based study. Highland Med Res J 2015;15(1):2-7
  37. Okpechi IG, Swanepoel CR, Venter F. Access to medications and conducting clinical trials in LMICs. Nat Rev Nephrol. 2015 Mar;11(3):189-194.
  38. Mutyaba A, Sonderup MW, Locketz M, Okpechi I, Spearman CW, Tooke A. Disseminated Emmonsia in an HIV-HBV co-infected man. ID Cases 2015; 2: 35–36
  39. Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I, Zhao MH, Lv J, Garg AX, Knight J, Rodgers A, Gallagher M, Kotwal S, Cass A, Perkovic V. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet. 2015;385(9981):1975-82.
  40. Spearman,CWN, Barday ZA. Immune tolerance and immunosuppression in solid organ transplantation. S Afr Med J 2014;104(11):795.
  41. Muller, E, Barday, Z, Mendelson, M, Kahn D. HIV-Positive–to–HIV-Positive Kidney Transplantation — Results at 3 to 5 Years. N Engl J Med 2015;372:613-20.
  42. Hodkinson B, Mapiye D, Jayne D, Kalla A, Tiffin N, Okpechi I. The African Lupus Genetics Network (ALUGEN) registry: standardized, prospective follow-up studies in African patients with systemic lupus erythematosus. Lupus. 2015 Sep 24. pii: 0961203315606984. [Epub ahead of print]
  43. Wearne N. Pregnancy and the kidneys. S Afr Med J 2014; Volume 104 no 9 Sept
  44. Tiffin N, Hodkinson B, Okpechi I. Lupus in Africa: can we dispel the myths and face the challenges? Lupus. 2014; 23 (1):102-11. 
  45. R.A. Tamayo Isla, D. Mapiye, C.R. Swanepoel,  N. Rozumyk, J.E. Hubahib, I.G. Okpechi. Continuous Ambulatory Peritoneal Dialysis (CAPD) in Limpopo South Africa: predictors of patient and technique survival. Perit Dial Int. 2014 Jul-Aug;34(5):518-25.
  46. Dandara C, Huzair F, Borda-Rodriguez A, Chirikure S, Okpechi I, Warnich L, Masimirembwa C. H3Africa and the African Life Sciences Ecosystem: Building Sustainable Innovation. OMICS. 2014 Dec;18(12):733-9
  47. De Andrade R, Kotze T, Lesosky M, Swanepoel C. Comparison of myocardial perfusion during hameodialysis and haemofiltration. Nephron Clin Pract 2014; 126: 151-8.
  48. Kalyesubula R, Wearne N, Semitala FC, Kasonde Bowa K. HIV associated renal and genitourinary co-morbidities in Africa. Journal of Acquired Immune Deficiency Syndromes  2014; 67: S68–S78
  49. Tiffin N, Adeyemo A, Okpechi I. A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus. Orphanet J Rare Dis. 2013 Jan 7; 8(1):2. .
  50. Ayodele OE, Okpechi IG, Swanepoel CR. Long-term renal outcome and complications in South Africans with proliferative lupus nephritis. Int Urol Nephrol. 2013 Jan 10. [Epub ahead of print]
  51. Ogah OS, Madukwe OO, Chukwuonye II, Onyeonoro UU, Ukegbu AU, Akhimien MO, Okpechi IG. Prevalence and determinants of hypertension in Abia State Nigeria: Insights from the Abia State Non-Communicable diseases and Cardiovascular Risk factors Survey. Ethn Dis. 2013;23 [2]:161–167
  52. 4. Ogah O.S, Madukwe O.O, Onyeonoro U.U, Chukwuonye I.I, Ukegbu A.U, Akhimien M.O, Okpechi IG. Cardiovascular risk factors and non-communicable diseases in Abia state, Nigeria: report of a community-based survey. Int J Med Biomed Res 2013;2(1):57-68
  53. Okpechi IG, Nthite T, Swanepoel CR. Health-Related Quality of life in haemodialysis and peritoneal dialysis patients in Cape Town South Africa. Saudi J Kidney Dis Transpl. 2013 May-Jun;24(3):519-26
  54. Chukwuonye II, Chuku A, Onyeonoro UU, Okpechi IG, Madukwe OO, Umeizudike TI, Ogah OS. Prevalence of abdominal obesity in Abia State, Nigeria: results of a population-based house-to-house survey. Diabetes Metab Syndr Obes. 2013;6:285-91. 
  55. Swanepoel CR, Wearne N, Okpechi IG. Nephrology in Africa-not yet uhuru. Nat Rev Nephrol. 2013 Aug 20. doi: 10.1038/nrneph.2013.168. [Epub ahead of print]
  56. Chukwuonye II, Chuku A, Okpechi IG, Onyeonoro UU, Madukwe OO, Okafor GO, Ogah OS. Socioeconomic status and obesity in Abia State, South East Nigeria. Diabetes Metab Syndr Obes. 2013 Oct 16;6:371-8
  57. Okpechi IG, Chukwuonye II, Tiffin N, Madukwe OO, Onyeonoro UU, Umeizudike TI, Ogah OS. Blood pressure Gradients and cardiovascular Risk Factors in Urban and Rural Populations in Abia State South Eastern Nigeria Using the WHO STEPwise Approach. PLoS ONE 09/2013; 8(9):e73403
  58. Okpechi IG, Rayner BL, Swanepoel CR. Peritoneal dialysis in Cape Town, South Africa. Perit Dial Int. 2012; 32(3): 254-60.
  59. Swanepoel CR, Wearne N, Duffield MS, Okpechi IG. The evolution of our knowledge of HIV-associated kidney disease in Africa. Am J Kidney Dis 2012; 60(4): 668-78.
  60. Kenyon C, Wearne N, Burton R, Meintjes G. The risks of concurrent treatment with tenofovir and aminoglycosides in patients with HIV-associated tuberculosis. South Afr J HIV Med. 2011; 12(1): 43-45.
  61. Okpechi IG, Duffield M, Swanepoel CR. Primary glomerular diseases: variations in disease types seen in Africa and Europe. Port J Nephrol Hypert 2012; 26 (1): 25-31
  62. Umeizudike T, Mabayoje M, Okany C, Abdulkareem F, Adeyomoye A, Okubadejo N, Okpechi IG. Prevalence of chronic kidney disease in HIV positive patients in Lagos, south-west Nigeria. Nephrology Reviews 2012; volume 4:22-26
  63. IG Okpechi, OE Ayodele, ESW Jones, CR Swanepoel. Outcome of patients with membranous lupus nephritis in Cape Town South Africa. Nephrol Dial Transplant. 2012 Sep;27(9):3509-15
  64. Okpechi IG, Ayodele OE, Rayner BL, Swanepeol CR. Kidney disease in elderly South Africans. Clin Nephrol 2012 Nov 29. [Epub ahead of print]
  65. E. M. Muller, Z. Barday, F. McCurdie, D. Kahn. Deceased donor organ transplantation: A single center experience from Cape Town, South Africa. Indian J Nephrol. 2012; 22(2): 86–87. doi: 10.4103/0971-4065.97108
  66. Nel D, Vogel J, Muller E, Barday Z, Kahn D. Slow Early Graft Function: A Neglected Entity after Renal Transplantation. Nephron Clin Pract 2012;120:c200-c204 (DOI: 10.1159/000340032)
  67. Muller E, Barday Z, Mendelson M, Kahn D. Renal transplantation between HIV-positive donors and recipients justified. S Afr Med J. 2012; 102(6): 497-8.
  68. M Mendelson, Z Barday, R Eastman, D Le Feuvre, S Candy, H Wu, C Swanepoel. Rapidly progressive post-transplant lymphoproliferative disease following withdrawal of sirolimus.  S Afr Med J 2012; 102(12): 924-928. DOI:10.7196/SAMJ.5500
  69. Trinder Y. Common and less common side effects of antihypertensive a general practitioner’s perspective. S Afr Fam Pract 2012; 54: S31-S32
  70. Swanepoel CR, Okpechi IG. HIV Renal Disease in Africa: The journey so far and future direction. Port J Nephrol Hypert 2011; 25(1): 11-15
  71. IG Okpechi, BL Rayner. ‘Impact of recent landmark clinical trials on hypertension treatment’ Clin Invest 2011; 1(8) 1141 – 1154
  72. IG Okpechi, CR Swanepoel, BL Rayner. The outcomes of rationing dialysis therapy for biopsy proven end-stage renal disease (ESRD) in South African Patients. J Nephrol 2011 DOI:10.5301/jn.5000032
  73. Vivian L, McLauglin S, Swanepoel C, Burch V. Teaching biopsychosocial competence and the principles of primary care (PHC) at the patient’s bedside. African Journal of Health Professions Education 2010; 2: 23-28.
  74. Ayodele O, Okpechi I, Swanepoel C. “Predictors of poor renal outcome in patients with biopsy-proven lupus nephritis” Nephrology 2010; 15: 482–490
  75. Arendse C, Okpechi IG, Swanepoel CR. Acute dialysis in HIV positive patients in Cape Town South Africa.” Nephrology 2010; doi: 10.1111/j.1440-1797.2010.01358.
  76. Chukwuonye II, Oviasu E, Agaba EI, Agbaji O, Idoko J, Onwuegbuzie G, Okafor UH, Adegbe E, Okpechi IG, Onwuchekwa UN. Glomerular Filtration Rate among HIV/AIDS patients at Jos University Teaching Hospital. Journal of Medicine in the Tropics. 2010; 12: 26 – 29
  77. Arendse C, Wearne N, Okpechi IG, Swanepoel CR. The Acute, the Chronic and the News of HIV Renal Disease in Africa. Kidney Int. 2010; 78: 239 – 245.
  78. Ameh OI, Swanepoel CR, Aderibigbe A, Kengne AP, Okpechi IG. Out of Africa: Complete and partial remissions as a combined outcome in patients with idiopathic membranous glomerulonephritis in Cape Town. Nephrology (Carlton) 2015 Dec 25. doi: 10.1111/nep.12703. [Epub ahead of print]
  79. Mbuli L, Mapiye D, Okpechi I. Lupus nephritis is associated with poor pregnancy outcomes in pregnant SLE patients in Cape Town: a retrospective analysis. The Pan African Medical Journal. 2015;22:365. doi:10.11604/pamj.2015.22.365.7897
  80. Okpechi IG, Gcelu A, Ameh OI. Lupus nephritis: An approach to diagnosis and treatment in South Africa. S Afr Med J 2015; 105(12):1071 – 1074
  81. Mangena P, Saban S, Hlabyago K, Rayner B. An approach to a young hypertensive. S Afr Med J 2016; 106: 36-38.